2024-03-28T20:59:05Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/45762020-12-10T09:01:24Zcom_10612_17col_10612_18
00925njm 22002777a 4500
dc
García, Juan J.
author
Diez, M. José
author
Sierra, Matilde
author
Terán, M. Teresa
author
2015-09-04
A compartmental and non-compartmental pharmacokinetic study was carried out on rabbits after intravenous (i.v.) administration of levamisole al the three dose rales: 12.5. 16.0 and 20.0 mg/kg body weight. Using compartmental analysis, the disposition of levamisole best fitted a t wo-compartmental open model with mean values of α= 0.1278, 0. 1019 and 0.1282 mi n - 1 ; β =0.0139
O.O 126 and 0.0124 min- 1 ; A = 6 .24. 5.27 and 10.58 µg/ml and β = 2.14. :3083
and 5.08 µg/ml for each dose, respectively. The statistical moment theory was mainly used for non-compartmental analysis. Values for mean residence time (MRT) of 69.2, 71 .7 and 73. 1 min were obtained for each dose. The mean values for volume of dist ribution at steady state ( Vd(ss)). determined by compartmental analysis, were 3879. 3 279 and 2735 ml/kg for each dose. and values obtained using the statistical moment theory were :3760. 3015 and 2943 ml/kg; there were no statistically significant differences using Student's paired 1-lest. Identical conclusions were obtained using both methods when the parameters β. AUC and Cl were compared.
Journal of Veterinary Pharmacology and Therapeutics, 1992, n. 15
http://hdl.handle.net/10612/4576
Ecología. Medio ambiente
Farmacología
Veterinaria
Pharmacokinetics of levamisole in rabbits after intravenous administration