2024-03-29T00:15:45Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/122732020-12-10T08:58:18Zcom_10612_17col_10612_18
BULERIA. Repositorio Institucional de la Universidad de León
author
Castaño Labajo, Pablo
author
Fernández Fernández, Miguel
author
Regidor Cerrillo, Javier
author
Fuertes Franco, Miguel
author
Horcajo Iglesias, María del Pilar
author
Ferré Pérez, Ignacio
author
Ferreras Estrada, María Del Carmen
author
Ortega Mora, Luis Miguel
author
Pérez Pérez, Valentín
author
Benavides Silván, Julio
other
Sanidad Animal
2020-06-23T14:35:39Z
2020-06-23T14:35:39Z
0928-4249
https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-019-0681-8
http://hdl.handle.net/10612/12273
https://doi.org/10.1186/s13567-019-0681-8
1297-9716
Although it is known that gestation could infuence the clinical course of ovine toxoplasmosis, the precise efect of the term of gestation when sheep are infected are yet mostly unknown. The aim of this study was to evaluate the peripheral and placental immune responses developed in pregnant sheep after experimental infection with Toxoplasma gondiiat diferent times of gestation. Thirty‑six pregnant sheep were allocated in diferent groups, orally inocu‑lated with sporulated oocysts of T. gondiiat early, mid and late gestation and culled within 30 days post‑infection. The peripheral humoral and cytokine responses were evaluated, as well as the transcription of cytokines at the placenta.
Serological analysis revealed that, regardless the term of gestation when infected, specifc IgG against T. gondiiwere detected from day 8 post‑infection and there was an early peripheral release of IFN‑γ at the frst week post‑infection followed by a short peak of IL10 and TNF‑α at the second week post‑infection. There were no signifcant diferences in this response between infected groups. At the placenta, a similar increase in transcription of IFN‑γ, and TNF‑α was found at the three terms of gestation, while IL‑4 increased mainly at the frst and second terms and IL‑10 transcription was higher at the last term. While these fndings show that both Th1 and Th2 cytokines play a key role in the patho‑genesis of ovine toxoplasmosis and that placental and peripheral immune responses do not closely correlate, there seems to be no clear modulation of these responses along the gestation.
Inmunología
Veterinaria
Peripheral and placental immune responses in sheep after experimental infection with "Toxoplasma gondii" at the three terms of gestation
info:eu-repo/semantics/article
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URL
https://buleria.unileon.es/bitstream/10612/12273/1/Peripheral%20and%20placental%20immune%20responses.pdf
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Peripheral and placental immune responses.pdf
URL
https://buleria.unileon.es/bitstream/10612/12273/3/Peripheral%20and%20placental%20immune%20responses.pdf.txt
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Peripheral and placental immune responses.pdf.txt