2024-03-29T15:36:09Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/45632020-12-10T09:01:13Zcom_10612_17col_10612_18
BULERIA. Repositorio Institucional de la Universidad de León
author
Fernández, Nélida
author
García, Juan J.
author
Sierra, Matilde
author
Diez, M. José
author
Terán, M. Teresa
other
Farmacologia
2015-09-04T11:33:27Z
2015-09-04T11:33:27Z
2015-09-04
New Zealand Veterinary Journal, 1997, n. 45
http://hdl.handle.net/10612/4563
The pharmacokinetics of levamisole at doses of 5, 7.5 and 10 mg/kg were determined after its intravenous administration to eighteen healthy Merino sheep. Using compartmental analysis, the disposition of the drug best fitted a two-compartmental open model. The mean values for the compartmental volume of distribution at steady state (Vss) were 2.034 ± 0.231, 2.347 ± 0.720 and
2.001 ± 0.367 l/kg for each dose, respectively, and values obtained using the statistical moment theory were 2.141 ± 0.269, 2.390
± 0.536 and 2.140 ± 0.345 l/kg for each dose, respectively. There were no dose-related differences (one-way ANOVA) in the constants describing distribution and elimination phases (α and β) or Vss but significant differences were detected in the total body clearance (CI) and the area under the plasma concentration-time curve (AUC). After non-compartmental analysis, no significant differences were found when the parameters λ. (the linear terminal slope) and Vss were compared, but significant differences were detected in CI and AUC. There were no significant differences between the values obtained using the compartmental and non compartmental analysis when λ.- β, CI, V,, and AUC were compared.
Farmacología
Zoología
Pharmacokinetics of levamisole in sheep after intravenous administration
info:eu-repo/semantics/article
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URL
https://buleria.unileon.es/bitstream/10612/4563/1/New%20Zealand%20Veterinary%20Journal%2c%201997%2c%20p.%2063-66%20
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New Zealand Veterinary Journal, 1997, p. 63-66
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https://buleria.unileon.es/bitstream/10612/4563/3/Levamisole%20sheep.pdf.txt
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Levamisole sheep.pdf.txt
URL
https://buleria.unileon.es/bitstream/10612/4563/4/New%20Zealand%20Veterinary%20Journal%2c%201997%2c%20p.%2063-66%20.txt
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New Zealand Veterinary Journal, 1997, p. 63-66 .txt