2024-03-29T01:54:02Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/47052020-12-10T08:56:56Zcom_10612_17col_10612_18
Fernández, Nélida
Hernandez, Luis
Sierra, Matilde
Diez, M. José
Calle Pardo, Ángela Pilar
Carriedo, Demetrio
Sahagún, Ana M.
Anguera, Anna
García, Juan J.
2015-10-21T14:18:03Z
2015-10-21T14:18:03Z
2015-10-21
BMC complementary and alternative medicine, 2014, n. 14
http://hdl.handle.net/10612/4705
Background: Plantago ovata husk therapy could be used in patients with Parkinson disease to reduce the
symptoms of gastrointestinal disorders, but it is important to know whether this compound modifies levodopa
pharmacokinetics. The maintenance of constant plasma concentrations of levodopa abolishes the clinical
fluctuations in parkinsonian patients. The aim of this randomised clinical trial was to establish the influence of the
fiber Plantago ovata husk in the pharmacokinetics of levodopa when administered to Parkinson patients well
controlled by their oral medication.
Methods: To evaluate the effects of this fiber on several biochemical parameters. 18 volunteers participated in
the study and received alternatively two treatments (Plantago ovata husk or placebo) with their usual
levodopa/carbidopa oral dose. On days 0 (initial situation), 14 and 35 of the study, blood samples were taken to
assess levodopa pharmacokinetics and to determine biochemical parameters.
Results: Levodopa Cmax was very similar in the initial situation (603.2 ng/ml) and after placebo administration
(612.0 ng/ml), being slightly lower (547.8 ng/ml) when Plantago ovata husk was given. AUC was very similar in
the three groups: initial situation.- 62.87 μg.min/ml, fiber treatment.- 64.47 μg.min/ml and placebo treatment.- 65.10
μg.min/ml. Fiber reduced significantly the number of peaks observed in the levodopa concentrations, maintaining
concentrations more stable. No significant differences were found in total cholesterol, LDL-cholesterol and triglycerides
with the administration of Plantago ovata husk.
Conclusions: Plantago ovata husk administration caused a smoothing and homogenization of levodopa absorption,
providing more stable concentrations and final higher levels, resulting in a great benefit for patients.
Ecología. Medio ambiente
Farmacología
Medicina. Salud
A randomised clinical trial to evaluate the effects of Plantago ovata husk in Parkinson patients: changes in levodopa pharmacokinetics and biochemical parameters
info:eu-repo/semantics/article