2024-03-28T11:30:36Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/108832020-12-10T09:04:11Zcom_10612_17col_10612_18
Effects of a resistance-training programme on endoplasmic reticulum unfolded protein response and mitochondrial functions in PBMCs from elderly subjects
Estébanez González, Brisamar
Moreira, Osvaldo Costa
Almar Galiana, Maríamar
Paz Fernández, José Antonio de
González-Gallego, Javier
Cuevas González, María José
Fisiologia
Facultad de Veterinaria
Educación Física
Fisiología
Retículo endoplásmico
Envejecimiento
Ejercicio físico
10 p.
Aging has been related with a decline in the ability to handle protein folding, which leads to endoplasmic reticulum stress and alterations in unfolded protein response (UPR). Importantly, physical activity could activate the UPR and attenuate or prevent age-induced endoplasmic reticulum (ER) dysfunction. The current study evaluated the effects of a resistance exercise on UPR and mitochondrial functions in peripheral blood mononuclear cells (PBMCs) from elderly subjects. Thirty healthy women and men (age, 72.8, sx− = 2.2 years) were randomized to a training group, which performed an 8-week resistance training programme, or a control group, which followed their daily routines. The phosphorylation of PERK and IRE1, as well as ATF4, and XBP1 protein expression, significantly increased following the training, while expression of BiP, AFT6 and CHOP remain without changes. Additionally, the intervention also induced an increase in PGC-1α and Mfn1 protein levels, while no changes were found in Drp1 expression. Finally, the resistance protocol was not able to activate PINK1/Parkin and Bnip3/Nix pathways. The results obtained seem to indicate that 8-week resistance exercise activates the UPR, stimulates mitochondrial biogenesis, maintains mitochondrial dynamics and prevents mitophagy activation by unfolded proteins in PBMCs from elderly subjects.
SI
2018
2019-06-15T16:02:34Z
2019-06-15T16:02:34Z
2019-06-15
info:eu-repo/semantics/article
European Journal of Sport Science, 2018, Jan 7
https://doi.org/10.1080/17461391.2018.1561950
http://hdl.handle.net/10612/10883
eng
info:eu-repo/semantics/openAccess
Taylor&Francis Online