2024-03-28T08:50:18Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/122922020-12-10T08:58:46Zcom_10612_17col_10612_18
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution
Castaño Labajo, Pablo
Fuertes Franco, Miguel
Regidor Cerrillo, Javier
Ferré Pérez, Ignacio
Fernández Fernández, Miguel
Ferreras Estrada, María Del Carmen
Moreno Gonzalo, Javier
González Lanza, María del Camino
Pereira Bueno, Juana María
Katzer, Frank
Ortega Mora, Luis Miguel
Pérez Pérez, Valentín
Benavides Silván, Julio
Sanidad Animal
Facultad de Veterinaria
Veterinaria
Ganado ovino
Toxoplasmosis
Embarazo
Parásitos
2401.12 Parasitología Animal
P. 1-14
The relation between gestational age and foetal death risk in ovine toxoplasmosis is already known, but the mechanisms involved are not yet clear. In order to study how the stage of gestation influences these mechanisms, pregnant sheep of the same age and genetic background were orally dosed with 50 oocysts of Toxoplasma gondii (M4 isolate) at days 40 (G1), 90 (G2) and 120 (G3) of gestation. In each group, four animals were culled on the second, third and fourth week post infection (pi) in order to evaluate parasite load and distribution, and lesions in target organs. Ewes from G1 showed a longer period of hyperthermia than the other groups. Abortions occurred in all groups. While in G2 they were more frequent during the acute phase of the disease, in G3 they mainly occurred after day 20 pi. After challenge, parasite and lesions in the placentas and foetuses were detected from day 19 pi in G3 while in G2 or G1 they were only detected at day 26 pi. However, after initial detection at day 19 pi, parasite burden, measured through RT-PCR, in placenta or foetus of G3 did not increase significantly and, at in the third week pi it was lower than that measured in foetal liver or placenta from G1 to G3 respectively. These results show that the period of gestation clearly influences the parasite multiplication and development of lesions in the placenta and foetus and, as a consequence, the clinical course in ovine toxoplasmosis.
SI
2016-03-16
2020-07-07T11:05:21Z
2020-07-07T11:05:21Z
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
0928-4249
https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-016-0327-z
http://hdl.handle.net/10612/12292
https://doi.org/10.1186/s13567-016-0327-z
1297-9716
eng
info:eu-repo/semantics/openAccess
Springer