2024-03-28T21:12:38Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/88012023-06-08T11:36:28Zcom_10612_17col_10612_18
Facultad de Veterinaria
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500
García Mateos, Dafne
b804c8e1-24c2-46a9-bb9f-ea36126c7da4
500
García-Villalba, Rocío
ea402235-8c74-4b98-8579-cb6a1ae7f2b9
500
Otero, Jon Andoni
b3d4f708-3282-43ec-8ad3-a3a3a8e49cc0
500
Marañón, José Ángel
ed3b52ac-dca3-4204-bb3f-6f1ff6fd22d2
500
Espín, Juan Carlos
c835445e-c5ef-4a86-a01f-fd07ea0b3a4b
500
Álvarez de Felipe, Ana Isabel
49
500
0000-0001-9206-9539
Merino Peláez, Gracia
732
500
0000-0002-7620-3475
Fisiologia
3882f52d-a532-4145-93b6-3bbeed487fef
500
2018-01-15
2018-10-15T12:15:50Z
2018-10-15T12:15:50Z
2018-10-15
Food & Function
http://hdl.handle.net/10612/8801
25 p.
Lignans are dietary polyphenols, which are metabolized by the gut microbiota into the
phytoestrogenic metabolites enterolignans, mainly enterolactone and enterodiol. The Breast
Cancer Resistance Protein (BCRP/ABCG2) is an efflux transporter that affects plasma and
milk secretion of several drugs and natural compounds. We hypothesized here that Abcg2
could influence levels of lignans and their derived metabolites in target tissues.
Consequently, we aimed to evaluate the role of Abcg2 in the tissue distribution of these
compounds. We used Abcg2-/- knockout and wild-type male mice fed with a lignanenriched
diet for one week and analysed plasma, small intestine, colon, liver, kidneys and
testicles. High levels of lignans as well as enterolignans and their glucuronide and sulfate
conjugates in the small intestine and colon were detected, with higher concentrations of the
conjugates in the wild-type compared with Abcg2-/- mice. Particularly relevant was the
detection of 24-fold and 8-fold higher concentrations of enterolactone-sulfate and
enterolactone-glucuronide, respectively, in the kidney of Abcg2-/- compared with wild-type
mice. In conclusion, our study showed that lignans and their derived metabolites were in
vivo substrates of Abcg2, which affected their plasma and tissue levels. These results
highlight the role of Abcg2 in influencing the health-beneficial properties of dietary
lignans
eng
Royal Society of Chemistry
Fisiología
Cáncer
BCRP/ABCG2
Proteínas
The Breast Cancer Resistance Protein (BCRP/ABCG2) as a key player in the tissue distribution of flaxseed lignans and their metabolites
info:eu-repo/semantics/preprint
THUMBNAIL
Breat cancer resistence.pdf.jpg
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TEXT
Breat cancer resistence.pdf.txt
Breat cancer resistence.pdf.txt
Extracted text
text/plain
33012
https://buleria.unileon.es/bitstream/10612/8801/3/Breat%20cancer%20resistence.pdf.txt
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ORIGINAL
Breat cancer resistence.pdf
Breat cancer resistence.pdf
application/pdf
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https://buleria.unileon.es/bitstream/10612/8801/1/Breat%20cancer%20resistence.pdf
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LICENSE
license.txt
license.txt
text/plain; charset=utf-8
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https://buleria.unileon.es/bitstream/10612/8801/2/license.txt
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10612/8801
oai:buleria.unileon.es:10612/8801
2023-06-08 13:36:28.849
BULERIA. Repositorio Institucional de la Universidad de León
buleria@unileon.es
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