RT info:eu-repo/semantics/article
T1 Endoplasmic reticulum unfolded protein response, aging and exercise: an update
A1 Estébanez González, Brisamar
A1 Paz Fernández, José Antonio de
A1 Cuevas González, María José
A1 González Gallego, Javier
A2 Fisiologia
K1 Educación Física
K1 Fisiología
K1 Retículo endoplásmico
K1 Envejecimiento
K1 Ejercicio físico
AB The endoplasmic reticulum (ER) is a dynamic and multifunctional organelle responsiblefor protein biosynthesis, folding, assembly and modifications. Loss of protein foldingregulation, which leads to unfolded or misfolded proteins accumulation inside the ERlumen, drives ER stress (ERS) and unfolded protein response (UPR) activation. Duringaging, there is a decline in the ability of the cell to handle protein folding, accumulationand aggregation, and the function of UPR is compromised. There is a progressivefailure of the chaperoning systems and a decline in many of its components, so thatthe UPR activation cannot rescue the ERS. Physical activity has been proposed asa powerful tool against aged-related diseases, which are linked to ERS. Interventionalstudies have demonstrated that regular exercise is able to decrease oxidative stressand inflammation and reverse mitochondrial and ER dysfunctions. Exercise-inducedmetabolic stress could activate the UPR since muscle contraction is directly involvedin its activation, mediating exercise-induced adaptation responses. In fact, regularmoderate-intensity exercise-induced ERS acts as a protective mechanism againstcurrent and future stressors. However, biological responses vary according to exerciseintensity and therefore induce different degrees of ERS and UPR activation. This articlereviews the effects of aging and exercise on ERS and UPR, also analyzing possiblechanges induced by different types of exercise in elderly subjects.
PB Frontiers Media SA
YR 2019
FD 2019-06-16
LK http://hdl.handle.net/10612/10928
UL http://hdl.handle.net/10612/10928
NO Frontiers in Physiology, 2018, vol. 9, art. 1744
NO 9 p.
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 18-abr-2024