RT info:eu-repo/semantics/article
T1 Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution
A1 Castaño Labajo, Pablo
A1 Fuertes Franco, Miguel
A1 Regidor Cerrillo, Javier
A1 Ferré Pérez, Ignacio
A1 Fernández Fernández, Miguel
A1 Ferreras Estrada, María Del Carmen
A1 Moreno Gonzalo, Javier
A1 González Lanza, María del Camino
A1 Pereira Bueno, Juana María de la Cruz
A1 Katzer, Frank
A1 Ortega Mora, Luis Miguel
A1 Pérez Pérez, Valentín
A1 Benavides Silván, Julio
A2 Sanidad Animal
K1 Veterinaria
K1 Ganado ovino
K1 Toxoplasmosis
K1 Embarazo
K1 Parásitos
K1 2401.12 Parasitología Animal
AB The relation between gestational age and foetal death risk in ovine toxoplasmosis is already known, but the mechanisms involved are not yet clear. In order to study how the stage of gestation influences these mechanisms, pregnant sheep of the same age and genetic background were orally dosed with 50 oocysts of Toxoplasma gondii (M4 isolate) at days 40 (G1), 90 (G2) and 120 (G3) of gestation. In each group, four animals were culled on the second, third and fourth week post infection (pi) in order to evaluate parasite load and distribution, and lesions in target organs. Ewes from G1 showed a longer period of hyperthermia than the other groups. Abortions occurred in all groups. While in G2 they were more frequent during the acute phase of the disease, in G3 they mainly occurred after day 20 pi. After challenge, parasite and lesions in the placentas and foetuses were detected from day 19 pi in G3 while in G2 or G1 they were only detected at day 26 pi. However, after initial detection at day 19 pi, parasite burden, measured through RT-PCR, in placenta or foetus of G3 did not increase significantly and, at in the third week pi it was lower than that measured in foetal liver or placenta from G1 to G3 respectively. These results show that the period of gestation clearly influences the parasite multiplication and development of lesions in the placenta and foetus and, as a consequence, the clinical course in ovine toxoplasmosis.
PB Springer
SN 0928-4249
LK http://hdl.handle.net/10612/12292
UL http://hdl.handle.net/10612/12292
NO P. 1-14
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 30-jun-2024