RT info:eu-repo/semantics/article
T1 Gene Networks Driving Genetic Variation in Milk and Cheese-Making Traits of Spanish Assaf Sheep
A1 Marina García, Héctor
A1 Reverter, Antonio
A1 Gutiérrez Gil, Beatriz
A1 Alexandre, Pâmela Almeida
A1 Porto-Neto, Laercio R.
A1 Suárez Vega, Aroa
A1 Li, Yutao
A1 Esteban Blanco, Cristina
A1 Arranz Santos, Juan José
A2 Producción Animal
K1 Genética
K1 Dairy sheep
K1 Milk coagulation properties
K1 Meta-analysis
K1 GWAS
K1 Linkage disequilibrium
AB Most of the milk produced by sheep is used for the production of high-quality cheese. Consequently, traits related to milk coagulation properties and cheese yield are economically important to the Spanish dairy industry. The present study aims to identify candidate genes and their regulators related to 14 milk and cheese-making traits and to develop a low-density panel of markers that could be used to predict an individual’s genetic potential for cheese-making efficiency. In this study, we performed a combination of the classical genome-wide association study (GWAS) with a stepwise regression method and a pleiotropy analysis to determine the best combination of the variants located within the confidence intervals of the potential candidate genes that may explain the greatest genetic variance for milk and cheese-making traits. Two gene networks related to milk and cheese-making traits were created using the genomic relationship matrices built through a stepwise multiple regression approach. Several co-associated genes in these networks are involved in biological processes previously found to be associated with milk synthesis and cheese-making efficiency. The methodology applied in this study enabled the selection of a co-association network comprised of 374 variants located in the surrounding of genes showing a potential influence on milk synthesis and cheese-making efficiency.
PB MDPI
LK http://hdl.handle.net/10612/13489
UL http://hdl.handle.net/10612/13489
NO Artículo de Investigación
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 26-abr-2024