RT info:eu-repo/semantics/article
T1 Assessing the effect of β-glucan diets on innate immune response of tilapia macrophages against trichlorfon exposure: an in vitro study
A1 Fierro Castro, María Camino
A1 Tort, Lluís
A1 Mingatto, Fábio Erminio
A1 Biller, Jaqueline Dalbello
A1 Fierro-Castro, Camino
A2 Genetica
K1 Biología
K1 Aquatic contaminants
K1 Trichlorfon
K1 Organophosphates
K1 Innate immunity
K1 Immunomodulation
K1 Oreochromis niloticus
K1 2415 Biología Molecular
AB [EN] The widespread use of pesticides in some areas where fish species such as tilapia are farmed may cause damage to the environment and affect commercial fish and therefore, human health. Water leaching with the pesticide trichlorfon, during the fumigation season in the field, can affect water quality in fish farms and consequently affect fish health. At the same time, the use of immunomodulatory compounds such as β-glucan supplied in the diet has become widespread in fish farms as it has been shown that improves the overall immune response. The present research examines the immunomodulatory impacts observed in macrophages of Nile tilapia (Oreochromis niloticus) after being fed a diet supplemented with β-glucan for 15 days, followed by their in vitro exposure to trichlorfon, an organophosphate pesticide, at concentrations of 100 and 500 µg mL−1 for 24 h. The results showed that β-glucan diet improved the viability of cells exposed to trichlorfon and their antioxidant capacity. However, β-glucan did not counteract the effects of the pesticide as for the ability to protect against bacterial infection. From the present results, it can be concluded that β-glucan feeding exerted a protective role against oxidative damage in cells, but it was not enough to reduce the deleterious effects of trichlorfon on the microbicidal capacity of macrophages exposed to this pesticide.
PB Springer
SN 0920-1742
LK https://hdl.handle.net/10612/17560
UL https://hdl.handle.net/10612/17560
NO Fierro-Castro, C., Tort, L., Mingatto, F. E., & Biller, J. D. (2023). Assessing the effect of β-glucan diets on innate immune response of tilapia macrophages against trichlorfon exposure: an in vitro study. Fish Physiology and Biochemistry. https://doi.org/10.1007/S10695-023-01283-5
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 19-may-2024