RT info:eu-repo/semantics/article
T1 Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
A1 Seco Calvo, Jesús Ángel
A1 Sánchez Herráez, Sergio
A1 Casis, Luis
A1 Valdivia, Asier
A1 Pérez Urzelai, Itxaro
A1 Gil, Javier
A1 Echevarría, Enrique
A2 Fisioterapia
K1 Medicina. Salud
K1 Synovial fluid
K1 Peptidase activity
K1 Knee osteoarthritis
AB [EN]AimsTo analyze the potential role of synovial fluid peptidase activity as a measure of disease bur-den and predictive biomarker of progression in knee osteoarthritis (KOA).MethodsA cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years(SD 1.15) with advanced KOA (Ahlbäck grade > 3 and clinical indications for arthrocentesis)recruited through the (Orthopaedic Department at the Complejo Asistencial Universitariode León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopep-tidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase(PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamylaminopeptidase (PGAP).resultsSynovial fluid peptidase activity varied significantly as a function of clinical signs, with dif-ferences in levels of PEP (p = 0.020), ASP (p < 0.001), and PGAP (p = 0. 003) associated withknee locking, PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p = 0.000) withknee failure, and PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p < 0.001)with knee effusion. Further, patients with the greatest functional impairment had signifi-cantly higher levels of APB (p = 0.005), PEP (p = 0.005), ASP (p = 0.006), GLU (p = 0.020),and PGAP (p < 0.001) activity, though not of NAP or PSA, indicating local alterations in therenin-angiotensin system. A binary logistic regression model showed that PSA was protective(p = 0.005; Exp (B) 0.949), whereas PEP (p = 0.005) and GLU were risk factors (p = 0.012).ConclusionThese results suggest synovial fluid peptidase activity could play a role as a measure of dis-ease burden and predictive biomarker of progression in KOA.
PB The British Editorial Society of Bone & Joint Surgery,
LK https://hdl.handle.net/10612/17617
UL https://hdl.handle.net/10612/17617
NO Seco-Calvo, J., Sánchez-Herráez, S., Casis, L., Valdivia, A., Perez-Urzelai, I., Gil, J., & Echevarría, E. (2020). Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression. Bone & joint research, 9(11), 789–797. https://doi.org/10.1302/2046-3758.911.BJR-2020-0022.R2
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 18-may-2024