RT info:eu-repo/semantics/article
T1 The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens
A1 Río González, María Luisa del
A1 Rodríguez Barbosa, José Ignacio
A1 Schneider, Pascal
A1 Graca, Luis
A1 Buhler, Leo
A1 Pérez-Simón, José-Antonio
A2 Inmunologia
K1 Inmunología
K1 regulatory T cells
K1 lymphopenia
K1 homeostatic proliferation
K1 transplantation
K1 TNF/TNF receptors
K1 graft-versus-host disease
K1 graft rejection
K1 inmunología
AB [EN] Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-selfthrough cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansionlargely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumornecrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute topromote peripheral Tregs expansion and sustain their survival. This property can be leveraged toenhance tolerance to allogeneic transplants by tipping the balance of Tregs over conventional T cellsduring the course of immune reconstitution. This is of particular interest in peri-transplant toleranceinduction protocols in which T cell depletion is applied to reduce the frequency of alloreactive T cellsor in conditioning regimens that allow allogeneic bone marrow transplantation. These conditioningregimens are being implemented to limit long-term side effects of continuous immunosuppression andfacilitate the establishment of a state of donor-specific tolerance. Lymphopenia-induced homeostaticproliferation in response to cytoreductive conditioning is a window of opportunity to enhancepreferential expansion of Tregs during homeostatic proliferation that can be potentiated by agoniststimulation of TNFR
PB MDPI
SN 1422-0067
LK https://hdl.handle.net/10612/17621
UL https://hdl.handle.net/10612/17621
NO Rodriguez-Barbosa, J.-I., Schneider, P., Graca, L., Bühler, L., Perez-Simon, J.-A., & Del Rio, M.-L. (2020). The role of TNFR2 and DR3 in the in vivo expansion of tregs in t cell depleting transplantation regimens [Review of The role of TNFR2 and DR3 in the in vivo expansion of tregs in t cell depleting transplantation regimens]. International Journal of Molecular Sciences, 21(9). MDPI AG. https://doi.org/10.3390/IJMS21093347
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 29-jun-2024