RT info:eu-repo/semantics/article
T1 Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects
A1 Mejías Peña, Yubisay Noiraly
A1 Estébanez González, Brisamar
A1 Rodríguez Miguélez, Paula
A1 Fernández Gonzalo, Rodrigo
A1 Almar Galiana, Maríamar
A1 Paz Fernández, José Antonio de
A1 González Gallego, Javier
A1 Cuevas González, María José
A2 Fisiologia
K1 Fisiología
K1 elderly
K1 autophagy
K1 inflammasome
K1 apoptosis
K1 resistance exercise
K1 2410.10 Fisiología Humana
AB [EN]Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr) were randomized to a training (TG) or a control (CG) group. TG performed an 8-week resistance training program, while CG followed their daily routines. Protein expression of beclin-1, Atg12, Atg16 and LAMP-2 increased following the training program, while expression of p62/SQSTM1 and phosphorylation of ULK-1 at Ser757 were significantly lower. Resistance exercise also induced a decrease in NLRP3 expression and in the caspase-1/procaspase-1 ratio. Expression of Bcl-2 and Bcl-xL, as well as the Bad/BcL-2 ratio were reduced, and there was a significant decrease in the protein content of caspase-3. The results obtained seem to indicate that 8-week resistance training stimulates autophagy, prevents NLRP3 inflammasome activation, and reduces apoptosis in PBMCs from elderly subjects. These data could have a significant impact in prevention and rehabilitation programs currently employed in elderly population.
PB Board
LK https://hdl.handle.net/10612/17634
UL https://hdl.handle.net/10612/17634
NO Mejías-Peña, Y., Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Almar, M., de Paz, J. A., González-Gallego, J., & Cuevas, M. J. (2017). Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects. Aging, 9(2), 408-418. https://doi.org/10.18632/AGING.101167
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 26-jun-2024