RT info:eu-repo/semantics/article
T1 Improvement of albendazole bioavailability with menbutone administration in sheep
A1 Díez Láiz, Raquel
A1 Diez Liébana, María José
A1 García Viéitez, Juan José
A1 Rodríguez Lago, José Manuel
A1 López Cadenas, Cristina
A1 Fernández Martínez, María Nélida
A1 Sierra Vega, Matilde
A1 Sahagún Prieto, Ana María
A2 Farmacologia
K1 Farmacología
K1 Veterinaria
K1 Albendazole
K1 Albendazole sulfoxide
K1 Albendazole sulfone
K1 Bioavailability
K1 Interaction
K1 Menbutone
K1 Pharmacokinetics
K1 Sheep
K1 3109 Ciencias Veterinarias
K1 3109.08 Farmacología
AB [EN] The pharmacokinetic interaction between a benzimidazole (albendazole, ABZ) and a choleretic drug (menbutone, MEN) was evaluated in sheep. The plasma disposition of albendazole sulfoxide (ABZSO, active metabolite) and albendazole sulfone (ABZSO2, inactive metabolite) was investigated following an oral administration of albendazole (ABZ) (5 mg/kg) alone or with menbutone (MEN) (intramuscular, 10 mg/kg). Blood samples were collected over 3 days post-treatment, and drug plasma concentrations were measured by high performance liquid chromatography (HPLC). ABZSO was measured from 0.5 to 48 h, and ABZSO2 from 2 to 60 h. No parent drug was detected at any sampling time. Mean maximum plasma concentration (Cmax) and the area under the plasma concentration-time curve (AUC) were 12.8% and 21.5% higher for ABZSO when ABZ and MENwere administered together, which indicates a significant increase in the amount absorbed. The rate of absorption was not modified, with similar values for the time to reach Cmax (tmax) (11.5 h with ABZ + MEN and 10.7 h with ABZ treatment), although no significant differences were observed for these latter pharmacokinetic parameters. Regarding ABZSO2, Cmax, AUC and tmax values were similar after both treatments (ABZ or ABZ + MEN). The results obtained indicate that co-administration of ABZ and MEN may be an interesting and practical option to increase the efficacy of this anthelmintic.
PB MDPI
LK https://hdl.handle.net/10612/17728
UL https://hdl.handle.net/10612/17728
NO .Diez, R., Diez, M. J., Garcia, J. J., Rodríguez, J. M., Lopez, C., Fernandez, N., Sierra, M., & Sahagun, A. M. (2022). Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep. Animals, 12(4). https://doi.org/10.3390/ANI12040463
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 30-jun-2024