RT info:eu-repo/semantics/article
T1 Miltefosine and nifuratel combination: a promising therapy for the treatment of leishmania donovani visceral leishmaniasis
A1 Melcón Fernández, Estela
A1 Galli, Giulio
A1 García Estrada, Carlos
A1 Balaña Fouce, Rafael
A1 Reguera Torres, Rosa María
A1 Pérez Pertejo, Maria Yolanda
A2 Toxicologia
K1 Farmacología
K1 Medicina. Salud
K1 Leishmania
K1 Drug combinations
K1 Nifuratel
K1 Miltefosine
K1 Drug repurposing
K1 32 Ciencias Médicas
K1 3214 Toxicología
K1 3109 Ciencias Veterinarias
AB [EN] Visceral leishmaniasis is a neglected vector-borne tropical disease caused by Leishmania donovani and Leishmania infantum that is endemic not only in East African countries, but also in Asia, regions of South America and the Mediterranean Basin. For the pharmacological control of this disease, there is a limited number of old and, in general, poorly adherent drugs, with a multitude of adverse effects and low oral bioavailability, which favor the emergence of resistant pathogens. Pentavalent antimonials are the first-line drugs, but due to their misuse, resistant Leishmania strains have emerged worldwide. Although these drugs have saved many lives, it is recommended to reduce their use as much as possible and replace them with novel and more friendly drugs. From a commercial collection of anti-infective drugs, we have recently identified nifuratel-a nitrofurantoin used against vaginal infections-as a promising repurposing drug against a mouse model of visceral leishmaniasis. In the present work, we have tested combinations of miltefosine-the only oral drug currently used against leishmaniasis-with nifuratel in different proportions, both in axenic amastigotes from bone marrow and in intracellular amastigotes from infected Balb/c mouse spleen macrophages, finding a potent synergy in both cases. In vivo evaluation of oral miltefosine/nifuratel combinations using a bioimaging platform has revealed the potential of these combinations for the treatment of this disease.
PB MDPI
SN 1661-6596
LK https://hdl.handle.net/10612/17821
UL https://hdl.handle.net/10612/17821
NO Melcon-Fernandez, E., Galli, G., García-Estrada, C., Balaña-Fouce, R., Reguera, R. M., & Pérez-Pertejo, Y. (2023). Miltefosine and Nifuratel Combination: A Promising Therapy for the Treatment of Leishmania donovani Visceral Leishmaniasis. International journal of molecular sciences, 24(2), 1635. https://doi.org/10.3390/ijms24021635
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 16-jun-2024