RT info:eu-repo/semantics/article
T1 Intestinal microbiota modulation in obesity-related non-alcoholic fatty liver disease
A1 Porras Sanabria, David
A1 Nistal González, Maria Esther
A1 Martínez Flórez, Susana
A1 González Gallego, Javier
A1 García Mediavilla, María Victoria
A1 Sánchez Campos, Sonia
A2 Fisiologia
K1 Fisiología
K1 Non-alcoholic fatty liver disease (NAFLD)
K1 Obesity
K1 Intestinal microbiota
K1 Probiotics
K1 Prebiotics
K1 Polyphenols
K1 Fecal microbiota transplantation (FMT)
K1 Physical exercise
K1 3109.09 Fisiología
K1 32 Ciencias Médicas
AB [EN] Obesity and associated comorbidities, including non-alcoholic fatty liver disease (NAFLD), are a major concern to public well-being worldwide due to their high prevalence among the population, and its tendency on the rise point to as important threats in the future. Therapeutic approaches for obesity-associated disorders have been circumscribed to lifestyle modifications and pharmacological therapies have demonstrated limited efficacy. Over the last few years, different studies have shown a significant role of intestinal microbiota (IM) on obesity establishment and NAFLD development. Therefore, modulation of IM emerges as a promising therapeutic strategy for obesity-associated diseases. Administration of prebiotic and probiotic compounds, fecal microbiota transplantation (FMT) and exercise protocols have shown a modulatory action over the IM. In this review we provide an overview of current approaches targeting IM which have shown their capacity to counteract NAFLD and metabolic syndrome features in human patients and animal models.
PB Frontiers Media
LK https://hdl.handle.net/10612/17853
UL https://hdl.handle.net/10612/17853
NO Porras, D., Nistal González, E., Martínez-Flórez, S., González-Gallego, J., García-Mediavilla, M. V., & Sánchez-Campos, S. (2018). Intestinal microbiota modulation in obesity-related non-alcoholic fatty liver disease [Review of Intestinal microbiota modulation in obesity-related non-alcoholic fatty liver disease]. Frontiers in Physiology, 9. Frontiers Media S.A. https://doi.org/10.3389/FPHYS.2018.01813
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 21-may-2024