RT info:eu-repo/semantics/article
T1 Advances in nanoplasmonic biosensors for clinical applications
A1 Lechuga, Laura María
A1 Mauriz García, Elba
A1 Dey, Priyanka
A2 Enfermeria
K1 Química
K1 Surface-plasmon
K1 Resonanceendothelial
K1 Growth-factordna-methylation
K1 Detectionsensitive
K1 Detectionspr-biosensorultrasensitive
K1 Detectionbiomarker
K1 Detectiongold
K1 Nanoparticlesreal-timeprotein
AB Biomarkers are unquestionable biological indicators for diagnosis and therapeutic interventions providing appropriate classification of a wide range of health disorders and risk factors. Nonetheless, detection and quantification of biomarkers need to be tested with sufficient reliability by robust analytical methods in order to assure clinical performance in health care settings. Since the analytical performance is determined by the sensitivity and specificity of the method employed, techniques have been intensively refined in order to avoid misinterpretation of results and undesirable bias. Although biomarkers can be detected with the existing analytical techniques, to reproducibly quantify them in decentralized settings or remote locations with the required accuracy is still a challenge. Currently, only a few point-of-care devices for biomarkers evaluation are commercially available. Thus, more focused research efforts are needed to overcome those limitations in order to provide universal patient-centered care platforms. To this end, plasmonic biosensors can be conveniently used as portable diagnostic devices for attaining timely and cost-effective clinical outcomes. The development of enhanced performances based on nanoplasmonics technology opens the way for sensor miniaturization, multiplexing and point of care testing. This review covers recent advances and applications of plasmonic and nanoplasmonic biosensors intended for biomarker diagnosis in the clinical practice, including cancer, cardiovascular and neurodegenerative diseases. The review specially focuses on: (i) recent progress in plasmonics developments including the design of singular nanostructured surfaces, (ii) novel chemical functionalization strategies for the appropriate incorporation of the bioreceptors and (iii) plasmonic applications as real operative devices in the clinical field. Future prospects in the use of nanoplasmonic sensor platforms for personalised quantification and management of biomarkers directly in body fluids will also be discussed.
PB royal society of chemistry
SN 0003-2654
LK https://hdl.handle.net/10612/17904
UL https://hdl.handle.net/10612/17904
NO MaurizE.,DeyP.,LechugaL.M..Advancesinnanoplasmonic biosensorsforclinicalapplications.Analyst,(2019).144.: 7105-.10.1039/c9an00701f.
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 26-jun-2024