RT info:eu-repo/semantics/article
T1 Antimicrobial resistance in commensal Escherichia coli and Enterococcus spp. is influenced by production system, antimicrobial use, and biosecurity measures on Spanish pig farms
T2 La resistencia a los antimicrobianos en Escherichia coli y Enterococcus spp. comensales está influida por el sistema de producción, el uso de antimicrobianos y las medidas de bioseguridad en las explotaciones porcinas españolas
A1 Mencía Ares, Óscar
A1 Argüello Rodríguez, Héctor
A1 Puente Fernández, Héctor
A1 Gómez García, Manuel
A1 Manzanilla, Edgar G.
A1 Álvarez Ordóñez, Avelino
A1 Carvajal Urueña, Ana María
A1 Rubio Nistal, Pedro Miguel
A2 Sanidad Animal
K1 Sanidad animal
K1 Veterinaria
K1 Antibiotic usage
K1 Bioindicator
K1 Enterococcus spp.
K1 Escherichia coli
K1 One Health
K1 Swine
K1 Sustainable farming
K1 3109 Ciencias Veterinarias
K1 3104.08 Porcinos
AB [EN] Background Antimicrobial resistance (AMR) is a global public health threat consequence of antimicrobial use (AMU) in human and animal medicine. In food-producing animals factors such as management, husbandry or biosecurity may impact AMU. Organic and extensive Iberian swine productions are based on a more sustainable and eco-friendly management system, providing an excellent opportunity to evaluate how sustained differences in AMU impact the AMR in indicator bacteria. Here, we evaluate the usefulness of commensal Escherichia coli and Enterococcus spp. isolates as AMR bioindicators when comparing 37 Spanish pig farms from both intensive and organic-extensive production systems, considering the effect of AMU and biosecurity measures, the last only on intensive farms. Results The production system was the main factor contributing to explain the AMR differences in E. coli and Enterococcus spp. In both bacteria, the pansusceptible phenotype was more common (p < 0.001) on organic-extensive farms when compared to intensive herds. The microbiological resistance in commensal E. coli was, for most of the antimicrobials evaluated, significantly higher (p < 0.05) on intensive farms. In enterococci, the lincosamides usage revealed the association between AMR and AMU, with an increase in the AMR for erythromycin (p < 0.01), quinupristin-dalfopristin (p < 0.01) and the multidrug-resistant (MDR) phenotype (p < 0.05). The biosecurity measures implemented on intensive farms influenced the AMR of these bioindicators, with a slightly lower resistance to sulfamethoxazole (p < 0.01) and the MDR phenotype (p < 0.05) in E. coli isolated from farms with better cleaning and disinfection protocols. On these intensive farms, we also observed that larger herds had a higher biosecurity when compared to smaller farms (p < 0.01), with no significant associations between AMU and the biosecurity scores. Conclusions Overall, this study evidences that the production system and, to a lesser extent, the biosecurity measures, contribute to the AMR development in commensal E. coli and Enterococcus spp., with antimicrobial usage as the main differential factor, and demonstrates the potential value of these bacteria as bioindicators on pig farms in AMR surveillance programs.
PB BioMed Central Ltd.
SN 2055-5660
LK https://hdl.handle.net/10612/17946
UL https://hdl.handle.net/10612/17946
NO Mencía-Ares, O., Argüello, H., Puente, H., Gómez-García, M., Manzanilla, E. G., Álvarez-Ordóñez, A., Carvajal, A., & Rubio, P. (2021). Antimicrobial resistance in commensal Escherichia coli and Enterococcus spp. is influenced by production system, antimicrobial use, and biosecurity measures on Spanish pig farms. Porcine Health Management, 7(1). https://doi.org/10.1186/S40813-021-00206-1
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 17-may-2024