RT info:eu-repo/semantics/article
T1 Nodopathies in the Early Diagnosis of Axonal Forms of Guillain-Barré Syndrome
A1 Urdiales Sánchez, Sara
A1 González Montaña, José Ramiro
A1 Díaz Pérez, Ricardo
A1 Calvo Calleja, Pablo
A1 Gutiérrez Trueba, María Antonia
A1 Urdiales Urdiales, Javier
A2 Medicina y Cirugia Animal
K1 Veterinaria
K1 Acute motor axonal neuropathy
K1 Nerve conduction blocks
K1 Nodopathies
K1 Nodo-paranodopathies
K1 Regional variants
K1 Guillain-Barré syndrome
K1 3109 Ciencias Veterinarias
AB [EN] Introduction: Guillain-Barré syndrome (GBS) has been classified into demyelinating and axonal subtypes or forms, such as acute motor axonal neuropathy (AMAN) and regional pharyngeal-cervical-brachial variant (PCBv). Objective: To study the relationship between motor nerve conduction blocks (CBs) and prognosis in AMAN and PCBv. Patients and Methods: We retrospectively analyzed six cases of AMAN and PCBv with serial nerve conduction studies (NCS) and electromyography (EMG). Results: The serial NCS (1st−2nd and 3rd week) showed, as the most constant data, a decreased amplitude of the compound muscle action potential (CMAP) in 100% of cases. CBs were present in 66.6% of cases. EMG (3rd week) showed signs of severe denervation in 33.3%. All patients were treated from the 1st−2nd week of evolution with intravenous immunoglobulins (IVIGs). Patients with CBs (1st−2nd and 3rd week), showed reversible CBs or reversible conduction failure (RCF) and complete recovery at 1 month. Patients without CBs, with persistent reduced distal CMAP amplitude (dCMAP), showed severe acute denervation due to axonal degeneration (3rd week and 1st−3rd month) and a slow recovery of several months. Conclusions: Not all axonal forms of GBS have a poor prognosis. This study of AMAN and PCBv shows that patients with CBs can have reversible CBs or RCF, and good prognosis. Patients without CBs, with persistent reduction of dCMAP amplitude decrement, have severe acute denervation, and a worse prognosis. AMAN and PCBv have a continuous spectrum ranging from CBs due to dysfunction/disruption of Nodes of Ranvier, called nodopathies, with reversible CBs or RCF and good prognosis, to axonal degeneration with worse prognosis
PB Frontiers Media
LK https://hdl.handle.net/10612/18534
UL https://hdl.handle.net/10612/18534
NO Urdiales-Sánchez, S., González-Montaña, J.-R., Diaz-Pérez, R., Calvo-Calleja, P., Gutiérrez-Trueba, M.-A., & Urdiales-Urdiales, J. (2022). Nodopathies in the Early Diagnosis of Axonal Forms of Guillain-Barré Syndrome. Frontiers in Neurology, 13. https://doi.org/10.3389/FNEUR.2022.902172
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 21-jun-2024