RT info:eu-repo/semantics/article
T1 Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib
A1 Rodríguez Gil, Alfonso
A1 Escamilla Gómez, Virginia
A1 Nufer, Melanie
A1 Andújar Sánchez, Félix
A1 Lopes Ramos, Teresa
A1 Bejarano García, José Antonio
A1 García Guerrero, Estefanía
A1 Calderón Cabrera, Cristina
A1 Caballero Velázquez, Teresa
A1 García Calderón, Clara Beatriz
A1 Hernández Díaz, Paola
A1 Reguera Ortega, Juan Luis
A1 Rodríguez Torres, Nancy
A1 Martínez Cibrián, Nuria
A1 Rodríguez Barbosa, José Ignacio
A1 Villadiego, Javier
A1 Pérez-Simón, José-Antonio
A2 Sanidad Animal
K1 Sanidad animal
K1 T lymphocytes
K1 Ruxolitinib
K1 Host disease
K1 Leukemia
K1 3109 Ciencias Veterinarias
AB [EN] Donor derived regulatory T lymphocytes and the JAK1/2 kinase inhibitor ruxolitinib are currently being evaluated as therapeutic options in the treatment of chronic graft versus host disease (cGvHD). In this work, we aimed to determine if the combined use of both agents can exert a synergistic effect in the treatment of GvHD. For this purpose, we studied the effect of this combination both in vitro and in a GvHD mouse model. Our results show that ruxolitinib favors the ratio of thymic regulatory T cells to conventional T cells in culture, without affecting the suppressive capacity of these Treg. The combination of ruxolitinib with Treg showed a higher efficacy as compared to each single treatment alone in our GvHD mouse model in terms of GvHD incidence, severity and survival without hampering graft versus leukemia effect. This beneficial effect correlated with the detection in the bone marrow of recipient mice of the infused donor allogeneic Treg after the adoptive transfer.
PB Nature Research
LK https://hdl.handle.net/10612/18626
UL https://hdl.handle.net/10612/18626
NO Rodríguez-Gil, A., Escamilla-Gómez, V., Nufer, M., Andújar-Sánchez, F., Lopes-Ramos, T., Bejarano-García, J. A., García-Guerrero, E., Calderón-Cabrera, C., Caballero-Velázquez, T., García-Calderón, C. B., Hernández-Díaz, P., Reguera-Ortega, J. L., Rodríguez-Torres, N., Martínez-Cibrián, N., Rodríguez-Barbosa, J. I., Villadiego, J., & Pérez-Simón, J. A. (2022). Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib. Scientific Reports, 12(1). https://doi.org/10.1038/S41598-022-12407-X
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 30-jun-2024