RT info:eu-repo/semantics/article
T1 Prolonged QT Interval in SARS-CoV-2 Infection: Prevalence and Prognosis
A1 Farré, Núria
A1 Mojón, Diana
A1 Llagostera-Martín, Marc
A1 Belarte Tornero, Laia Carla
A1 Calvo-Fernández, Alicia
A1 Vallés, Ermengol
A1 Negrete, Alejandro
A1 García-Guimaraes, Marcos
A1 Bartolomé, Yolanda
A1 Fernández Llamas, Camino
A1 García-Durán, Ana B.
A1 Marrugat, Jaume
A1 Vaquerizo, Beatriz
A2 Ciencias de la Computacion e Inteligencia Artificial
K1 Medicina. Salud
K1 QT internal
K1 COVID-19
K1 Hydroxychloroquine
K1 Azithromycin
K1 Prognosis
K1 Death
K1 3205 Medicina Interna
K1 3205.05 Enfermedades Infecciosas
AB [EN] Background: The prognostic value of a prolonged QT interval in SARS-Cov2 infection isnot well known. Objective: To determine whether the presence of a prolonged QT on admission isan independent factor for mortality in SARS-Cov2 hospitalized patients. Methods: Single-centercohort of 623 consecutive patients with positive polymerase-chain-reaction test (PCR) to SARS Cov2,recruited from 27 February to 7 April 2020. An electrocardiogram was taken on these patients withinthe first 48 h after diagnosis and before the administration of any medication with a known effect onQT interval. A prolonged QT interval was defined as a corrected QT (QTc) interval >480 milliseconds.Patients were followed up with until 10 May 2020. Results: Sixty-one patients (9.8%) had prolongedQTc and only 3.2% had a baseline QTc > 500 milliseconds. Patients with prolonged QTc were older,had more comorbidities, and higher levels of immune-inflammatory markers. There were no episodesof ventricular tachycardia or ventricular fibrillation during hospitalization. All-cause death washigher in patients with prolonged QTc (41.0% vs. 8.7%, p < 0.001, multivariable HR 2.68 (1.58–4.55),p < 0.001). Conclusions: Almost 10% of patients with COVID-19 infection have a prolonged QTcinterval on admission. A prolonged QTc was independently associated with a higher mortality evenafter adjustment for age, comorbidities, and treatment with hydroxychloroquine and azithromycin.An electrocardiogram should be included on admission to identify high-risk SARS-CoV-2 patients.
PB MDPI
LK https://hdl.handle.net/10612/19085
UL https://hdl.handle.net/10612/19085
NO Farré, N., Mojón, D., Llagostera, M., Belarte-Tornero, L. C., Calvo-Fernández, A., Vallés, E., Negrete, A., García-Guimaraes, M., Bartolomé, Y., Fernández, C., García-Duran, A. B., Marrugat, J., and Vaquerizo, B. (2020). Prolonged qt interval in sars-cov-2 infection: Prevalence and prognosis. Journal of Clinical Medicine, 9(9), 1-15. https://doi.org/10.3390/JCM9092712
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 14-may-2024