RT info:eu-repo/semantics/article T1 Anti-inflammatory and regenerative effects of MKARE® Eggshell Membrane: An in vitro osteoarthritis model and placebo-controlled clinical study A1 Casado-Santos, Alejandro A1 La Nuez-García, Manuel A A1 Álvarez-Rodríguez, Patricia A1 González Cubero, Elsa A1 González Rodríguez, Yaiza A1 González Fernández, María Luisa A1 Villar Suárez, María Vega A2 Anatomia y Anatomia Patologicas Comparadas K1 Veterinaria K1 Eggshell K1 Eggshell membrane K1 Osteoarthritis K1 Pain K1 Chondrocytes K1 3109.01 Anatomía AB [EN]MKARE®, a 100% natural ingredient derived from fresh eggshell membrane (ESM), has a rich composition in bioactive compounds like collagen, hyaluronic acid, and elastin. These components are beneficial for managing osteoarthritis (OA) due to their anti-inflammatory and regenerative properties. Highlighting the significance of freshness, our research has shown that the effectiveness of MKARE® is higher than that of other commercial products based on ESM that have been stored for several days at room temperature, losing their bioactive compounds. This study explores the MKARE® anti-inflammatory capacity through an in vitro and clinical analyses, demonstrating its ability to alleviate OA symptoms and improve joint health. This underscores the crucial role of freshness in optimizing the therapeutic benefits. PB Elsevier SN 1756-4646 LK https://hdl.handle.net/10612/19231 UL https://hdl.handle.net/10612/19231 NO Casado-Santos, A.; La Nuez-García, M. A.; Álvarez-Rodríguez, P.; González Cubero, E.; González Rodríguez, Y.; González Fernández, M. L.; Villar Suárez, M. V. (2024). Anti-inflammatory and regenerative effects of MKARE® Eggshell Membrane: An in vitro osteoarthritis model and placebo-controlled clinical study. Journal of Functional Foods, 116, https://doi.org/10.1016/j.jff.2024.106119 DS BULERIA. Repositorio Institucional de la Universidad de León RD 21-jun-2024