RT info:eu-repo/semantics/article
T1 Association between combinations of genetic polymorphisms and epidemiopathogenic forms of bovine paratuberculosis
A1 Juste, Ramon A.
A1 Vázquez, Patricia
A1 Ruiz Larrañaga, Otsanda
A1 Iriondo, Mikel
A1 Manzano, Carmen
A1 Aguirre, Mikel
A1 Estonba, Andone
A1 Geijo, María V.
A1 Molina, Elena
A1 Sevilla, Iker A.
A1 Alonso Hearn, Marta
A1 Gómez, Nieves
A1 Pérez Pérez, Valentín
A1 Cortés, Adoración
A1 Garrido, Joseba M.
A2 Sanidad Animal
K1 Sanidad animal
K1 Infectious disease
K1 Veterinary medicine
K1 Immunology
K1 Genetics
K1 3109 Ciencias Veterinarias
AB [EN] Control of major mycobacterial diseases affecting livestock is a challenging issue that requires different approaches. The use of genetic markers for improving resistance to Mycobacterium avium subsp. paratuberculosis infection in cattle has been explored as a promising population strategy We performed paratuberculosis epidemiopathogenic phenotypic and genotypic characterization involving 24 SNPs in six candidate genes (NOD2, CD209, SLC11A1, SP110, TLR2 and TLR4) on 502 slaughtered Friesian cows. In the current study, we investigate whether recently proposed paratuberculosis (PTB) epidemiopathogenic (EP) forms (apparently free-AF, latent-LAT and patent-PAT) could be associated with some combination of these 24 SNPs. Best EP form grouping was obtained using a combination of 5 SNPs in four genes (CD209: rs210748127; SLC11A1: rs110090506; SP110: rs136859213 and rs110480812; and TLR2: rs41830058). These groups were defined according to the level of infection progression risk to patent epidemiopathogenic forms and showed the following distributions: LOWIN (low) with 39 (8%) cases (94.9% AF/5.1% LAT/0% PAT); LATIN (low) with 17 (3%) cases (5.9% AF/94.1% LAT/0% PAT); AVERIN (average) with 413 (82%) cases (52.1% AF/38.5% LAT/9.4% PAT) and PATIN (patent) with 33 (7%) cases (36.4% AF/24.2% LAT/39.4% PAT). Age of slaughter was significantly higher for LATIN (88.3 months) compared to AVERIN (65.3 months; p = 0.0007) and PATIN (59.1 months; p = 0.0004), and for LOWIN (73.9 months) compared to PATIN (p = 0.0233), and nearly significant compared to AVERIN (p = 0.0572) These results suggest that some selected genetic polymorphisms have a potential use as markers of PTB EP forms and thus add a new tool for the control of this widespread infection
PB Elsevier
SN 2405-8440
LK https://hdl.handle.net/10612/19308
UL https://hdl.handle.net/10612/19308
NO Juste, R. A., Vazquez, P., Ruiz Larrañaga, O., Iriondo, M., Manzano, C., Agirre, M., Estonba, A., Geijo, M. V., Molina, E., Sevilla, I. A., Alonso-Hearn, M., Gomez, N., Perez, V., Cortes, A., & Garrido, J. M. (2018). Association between combinations of genetic polymorphisms and epidemiopathogenic forms of bovine paratuberculosis. Heliyon, 4(2). https://doi.org/10.1016/J.HELIYON.2018.E00535
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 22-may-2024