RT info:eu-repo/semantics/article
T1 Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma
A1 Sekar, Divya
A1 Govene, Luisa
A1 Río González, María Luisa del
A1 Sirait-Fischer, Evelyn
A1 Fink, Annika
A1 Brüne, Bernhard
A1 Rodríguez Barbosa, José Ignacio
A1 Weigert, Andreas
A2 Inmunologia
K1 Inmunología
K1 Natural killer T cells
K1 Inflammation
K1 Cancer
K1 3109 Ciencias Veterinarias
AB [EN] Natural Killer T cells (NKT cells) are emerging as critical regulators of pro- and anti-tumor immunity, both at baseline and in therapeutic settings. While type I NKT cells can promote anti-tumor immunity, their activity in the tumor microenvironment may be limited by negative regulators such as inhibitory immune checkpoints.We observed dominant expression of B- and T-lymphocyte attenuator (BTLA) on type I NKT cells in polyoma middle T oncogene-driven (PyMT) murine autochthonous mammary tumors. Other immune checkpoint receptors, such as programmed cell death 1 (PD-1) were equally distributed among T cell populations. Interference with BTLA using neutralizing antibodies limited tumor growth and pulmonary metastasis in the PyMT model in a therapeutic setting, correlating with an increase in type I NKT cells and expression of cytotoxic marker genes. While therapeutic application of an anti-PD-1 antibody increased the number of CD8+ cytotoxic T cells and elevated IL-12 expression, tumor control was not established. Expression of ZBTB16, the lineage-determining transcription factor of type I NKT cells, was correlated with a favorable patient prognosis in the METABRIC dataset, and BTLA levels were instrumental to further distinguish prognosis in patents with high ZBTB16 expression. Taken together, these data support a role of BTLA on type I NKT cells in limiting anti-tumor immunity
PB MDPI
LK https://hdl.handle.net/10612/19370
UL https://hdl.handle.net/10612/19370
NO Sekar, D., Govene, L., Del Río, M.-L., Sirait-Fischer, E., Fink, A. F., Brüne, B., Rodriguez-Barbosa, J. I., & Weigert, A. (2018). Downregulation of BTLA on NKT cells promotes tumor immune control in a mouse model of mammary Carcinoma. International Journal of Molecular Sciences, 19(3). https://doi.org/10.3390/IJMS19030752
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 17-jun-2024