RT info:eu-repo/semantics/article
T1 Gender-related differences among patients with STEMI: a propensity score analysis
T2 Diferencias relacionadas con el sexo en pacientes con IAMCEST: análisis por puntuación de propensión
A1 Tomassini, Francesco
A1 Cerrato, Enrico
A1 Rolfo, Cristina
A1 Bianco, Matteo
A1 Lo Savio, Luca
A1 Quirós Carretero, Alicia
A1 Echevarria Pinto, Mauro
A1 Giolitto, Sara
A1 Tizzani, Emanuele
A1 Corleto, Antonella
A1 Quadri, Giorgio
A1 Tripodi, Rosario
A1 Minniti, Davide
A1 Varbella, Ferdinando
A2 Matematica Aplicada
K1 Estadística
K1 Medicina. Salud
K1 ST-segment elevation myocardial infarction
K1 Primary angioplasty
K1 Sex differences
K1 Outcomes
K1 Infarto agudo de miocardio con elevación del segmento ST
K1 Angioplastia primaria
K1 Diferencias por sexo
K1 Pronóstico
K1 1209 Estadística
K1 3205.01 Cardiología
AB [EN] Introduction and objectives: Female sex is believed to be a significant risk factor for mortality among patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary interventions (pPCI).Methods: We collected data on all consecutive STEMI patients treated with pPCI within 12 hours and compared the males vs the females. The primary endpoint was long-term mortality one month after hospital discharge. The secondary endpoint was 30-days mortality.Results: From March 2006 to December 2016, 1981 patients underwent pPCI at our hospital, 484 (24.4%) were females. Compared with men, women were older (mean age 71.3 ± 11.6 vs 62.9 ± 11.8 years, P < .001), less smokers (26.7% vs 72.7%; P < .001), more diabetic (28.0% vs 22.3%; P < .002), more hypertensive (69.6% vs 61.3%; P < .001), presented more often with shock at baseline (13.2% vs 9.0%; P = .006), had longer symptoms-to-balloon time frames (5.36 ± 3.97 vs 4.47 ± 3.67 hours; P < .001). Also, women were less likely to receive glycoprotein IIb-IIIa inhibitors (59.5% vs 71.4%; P < .001) and stents (79.5% vs 86.6%; P = .01). During the 30-day and long-term follow-up (mean 4.9 ± 3.2 years) the female sex was associated with a higher mortality rate (8.9% vs 4.0%, P < .001 and 23.8% vs 18.4%, P = .01, respectively). After propensity score matching, 379 men and 379 women were selected. Female sex continued to be associated with a higher death rate at 30 days (9.5% vs 5.5%; P = .039) but not in the long term among survivors (25.6% vs 21.4%; P = .170).Conclusions: Compared to men, women with STEMI undergoing pPCI had higher 30-day mortality rates. However, among survivors, the long-term mortality rate was similar. Even if residual confounding cannot be ruled out, this difference in the outcomes may be partially explained by biological sex-related differences.
PB Permanyer Publications
SN 2604-7322
LK https://hdl.handle.net/10612/20341
UL https://hdl.handle.net/10612/20341
NO Tomassini, F., Cerrato, E., Rolfo, C., Bianco, M., Lo Savio, L., Quiros, A., Echavarria-Pinto, M., Giolitto, S., Tizzani, E., Corleto, A., Quadri, G., Tripodi, R., Minniti, D., & Varbella, F. (2020). Gender-related differences among patients with STEMI: A propensity score analysis. REC: Interventional Cardiology, 2(1), 15-21. https://doi.org/10.24875/RECICE.M19000061
NO Supplementary data associated with this article can be found in the online version available at https://doi.org/ 10.24875/RECICE.M19000061.
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 26-jun-2024