RT info:eu-repo/semantics/article
T1 HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT
A1 Rodríguez Barbosa, José Ignacio
A1 Schneider, Pascal
A1 Weigert, Andreas
A1 Lee, Kyung-Mi
A1 Kim, Tae-Jin
A1 Pérez Simón, José Antonio
A1 Río González, María Luisa del
A2 Sanidad Animal
K1 Sanidad animal
K1 HVEM
K1 BTLA
K1 CD160
K1 LIGHT
K1 Biomarkers
K1 Immunotherapy
K1 3109 Ciencias Veterinarias
AB [EN] Temporal and spatial expression of cosignaling receptors and theirligands regulates the early stages of T-cell activation (signal 1,T-cell receptor (TCR) signaling and signal 2, costimulation/coinhibition), clonal expansion and T-cell survival during theirdifferentiation towards effector T cells. Once the inflammatorystimulus is eliminated, effector T cells return to homeostasis afterundergoing a contraction phase by activation-induced cell deathand the intervention of ligands for coinhibitory receptors, leavinga population of long-term memory T cells. The expression ofligands for coinhibitory receptors on hematopoietic cells and,more importantly, on non-hematopoietic cells of peripheraltissues is a key process in tuning the functional activity of effectorT cells to prevent excess tissue inflammation that may lead toimmunopathology and subsequent tissue dysfunction
PB Nature
SN 1672-7681
LK https://hdl.handle.net/10612/20636
UL https://hdl.handle.net/10612/20636
NO Rodríguez Barbosa, J. I., Schneider, P., Weigert, A., Lee, K.-M., Kim, T. J., Pérez Simón, J. A., & del Río, M. L. (2019). HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT. Cellular and Molecular Immunology, 16(7), 679-682. https://doi.org/10.1038/S41423-019-0241-1
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 30-jun-2024