RT info:eu-repo/semantics/article
T1 Successful healing of non-healing surgical wound based on the release of platelet-derived growth factors from single donor allogeneic platelet-RICH plasma with one freeze-thaw cycle: a case report after a 1-year follow-up
A1 Seco Calvo, Jesús Ángel
A1 Vidán Estévez, Julia María
A1 Sánchez Herráez, Sergio
A2 Fisioterapia
K1 Medicina. Salud
K1 Non-healing surgical wound
K1 Platelet-derived growth factors (PDGF)
K1 Allogenic plasma-rich-platelet (al-PRP)
K1 Freeze-thaw process
K1 Single donor apheresis
AB [EN] Background. Non-healing surgical wounds is a risk in certain patients. Recently, allogenic plasma-rich-platelet (PRP) is used such as regenerative treatment of different non-healing surgical wounds. Purpose. We explore the potential role of using platelet-derived growth factors from single donor PRP, with a freeze-thaw process, for the treatment of surgical scar ulcer. Methods. We have used a PRP preparation protocol that involved a single cycle of centrifugation at a mean speed of 2400–2800 rpm of donor blood taken with an apheresis machine. Results. To our knowledge, this is the first study using the platelet-derived growth factors (PDGF) from single donor apheresis, with a freeze-thaw process. Four weeks after daily application of al-PRP, the ulcer progressed satisfactorily; at six weeks, the ulcer had healed. Conclusion. We concluded that the healing of a surgical wound observed in our case, is promising and suggests that al-PRP might play a role in treating surgical scar ulcers. This must be confirmed in future studies.
PB Springer Nature
SN 2396-832X
LK https://hdl.handle.net/10612/21001
UL https://hdl.handle.net/10612/21001
NO Seco-Calvo, J., Vidán-Estévez, J. & Sánchez-Herráez, S. Successful healing of non-healing surgical wound based on the release of platelet-derived growth factors from single donor allogeneic platelet-RICH plasma with one freeze-thaw cycle: a case report after a 1-year follow-up. transl med commun 7, 14 (2022). https://doi.org/10.1186/s41231-022-00120-w
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 29-jun-2024