RT info:eu-repo/semantics/article
T1 Topical Application of Ozonated Oils for the Treatment of MRSA Skin Infection in an Animal Model of Infected Ulcer
A1 Silva, Vanessa
A1 Peirone, Cecília
A1 Capita González, Rosa María
A1 Alonso Calleja, Carlos
A1 Marqués Magallanes, José A.
A1 Pires, Isabel
A1 Maltez, Luis
A1 Pereira, José Eduardo
A1 Igrejas, Gilberto
A1 Poeta, Patrícia
A2 Nutricion y Bromatologia
K1 Sanidad animal
K1 Veterinaria
K1 MRSA
K1 Antimicrobial resistance
K1 Ozone
K1 Ozonated oil
K1 In vivo
K1 Diabetic foot ulcer
K1 3109 Ciencias Veterinarias
AB [EN] Diabetic foot ulcers are a common cause of morbidity in diabetic patients. One of the main pathogens found in these ulcers is methicillin-resistant Staphylococcus aureus (MRSA). MRSA often carries resistance to several classes of antibiotics and their infections are becoming harder to treat. Therefore, new alternatives are urgently needed. Thus, this study aimed to investigate the capacity of topical ozonated oil application on the treatment of early-stage skin infected with MRSA in an animal model. Ozonated oil was prepared from a mixture of oils subjected to a gas stream of O2/O3 mixture. SixteenWistar rats were inoculated by an intradermic injection of MRSA suspension, producing an abscess lesion. After 3 days, the skin epidermis was removed to open the wound. Group 1 received an application of oil mixture without ozone treatment and Group 2 received an application of ozonated oil. After the treatment period, skin was collected, colony-forming units (CFU) of bacteria were quantified and the histological analysis of the skin was carried out. Skin samples from the control 1 and 2 had a bacterial load was of 1.1 × 105 and 5.7 × 103 CFU/mL, respectively. Group 2 showed better wound healing from mild to moderate epidermal regeneration. Topical application of ozonated vegetable oil in MRSA-infected skin in rats showed a small reduction of the bacterial load and better wound healing
PB MDPI
LK https://hdl.handle.net/10612/21027
UL https://hdl.handle.net/10612/21027
NO Silva, V., Peirone, C., Capita, R., Alonso Calleja, C., Marqués Magallanes, J. A., Pires, I., Maltez, L., Pereira, J. E., Igrejas, G., & Poeta, P. (2021). Topical application of ozonated oils for the treatment of MRSA skin infection in an animal model of infected ulcer. Biology, 10(5). https://doi.org/10.3390/BIOLOGY10050372
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 26-jun-2024