RT info:eu-repo/semantics/article
T1 Analysis of cardiovascular risk factors for the viability of cornea donors: a case–control study
A1 Martínez Isasi, Santiago
A1 Montero Salinas, Alejandro
A1 Fieira Costa, Eva
A1 Suanzes Hernández, Jorge
A1 Fernández García, Daniel
A1 Gómez Salgado, Juan
A1 Rendal Vázquez, Esther
A2 Enfermeria
K1 Enfermería
K1 Cardiovascular phisiology
K1 Risk factors
K1 Cornea donors
K1 Study
K1 2411.03 Fisiología Cardiovascular
K1 3212 Salud Publica
K1 3205 Medicina Interna
AB [EN] Objective The main objective of the study was toevaluate the influence of arterial hypertension, diabetes,dyslipidaemia, smoking, alcoholism and COPD (chronicobstructive pulmonary disease) on the viability of theextracted tissue as well as the donor.Design Observational case–control study.Setting Regional hospital in Northern Spain.Participants 1517 corneas were registered.Interventions Patients’ medical history was reviewedafter corneal donation and evaluation. Previous medicalinformation (age, sex and cardiovascular risk factors(CVRFs)) and data related to the donor (type of donor), thecorneal tissue and its evaluation, and the viability of theimplant were collected.Results A total of 1517 corneas were registered and81.5% of the donors presented at least one CVRF. Inrelation to the viability of the donor, it was observed thathaving suffered from COPD reduced the viability of thedonor (no COPD: 93.8% vs COPD: 88%; OR=0.49; 95%CI: 0.28 to 0.84) while alcohol consumption increasedit (drinker or ex-drinker: 95.8% vs non-drinker: 92.5%;OR=1.84; 95% CI: 1.01 to 3.33). Regarding tissue viability,decreased viability was observed in the presence ofCOPD (no COPD: 72.5% vs COPD: 64; OR=0.67; 95% CI:0.47 to 0.96) and diabetes mellitus (no diabetes: 72.9%vs diabetes: 67.2%; OR=0.76; 95% CI: 0.58 to 0.99). Asregards the viability of the implant, a total of 1039 corneas(68.9%) were suitable, observing decreased viability whensuffering from COPD (no COPD: 69.8% vs COPD: 60.7%;OR=0.67; 95% CI: 0.47 to 0.94) and increased whenhaving an active smoking habit (no habit: 65.3% vs habit:74.1%; OR=1.52; 95% CI: 1.21 to 1.91).Conclusions Through this study, it can be concluded thatin the absence of absolute exclusion criteria for donors, theassessment of how CVRF, alcoholism and COPD may affectthe donor provides details about the quality of the tissue tobe obtained.
PB BMJ
SN 2044-6055
LK https://hdl.handle.net/10612/21329
UL https://hdl.handle.net/10612/21329
NO Montero-Salinas, A., Martínez-Isasi, S., Fieira-Costa, E., Suanzes-Hernández, J., Fernández-García, D., Gómez-Salgado, J., & Rendal-Vazquez, E. (2023). Analysis of cardiovascular risk factors for the viability of cornea donors: A case-control study. BMJ Open, 13(12). https://doi.org/10.1136/BMJOPEN-2023-077122
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 29-jun-2024