RT info:eu-repo/semantics/article T1 Analysis of cardiovascular risk factors for the viability of cornea donors: a case–control study A1 Martínez Isasi, Santiago A1 Montero Salinas, Alejandro A1 Fieira Costa, Eva A1 Suanzes Hernández, Jorge A1 Fernández García, Daniel A1 Gómez Salgado, Juan A1 Rendal Vázquez, Esther A2 Enfermeria K1 Enfermería K1 Cardiovascular phisiology K1 Risk factors K1 Cornea donors K1 Study K1 2411.03 Fisiología Cardiovascular K1 3212 Salud Publica K1 3205 Medicina Interna AB [EN] Objective The main objective of the study was toevaluate the influence of arterial hypertension, diabetes,dyslipidaemia, smoking, alcoholism and COPD (chronicobstructive pulmonary disease) on the viability of theextracted tissue as well as the donor.Design Observational case–control study.Setting Regional hospital in Northern Spain.Participants 1517 corneas were registered.Interventions Patients’ medical history was reviewedafter corneal donation and evaluation. Previous medicalinformation (age, sex and cardiovascular risk factors(CVRFs)) and data related to the donor (type of donor), thecorneal tissue and its evaluation, and the viability of theimplant were collected.Results A total of 1517 corneas were registered and81.5% of the donors presented at least one CVRF. Inrelation to the viability of the donor, it was observed thathaving suffered from COPD reduced the viability of thedonor (no COPD: 93.8% vs COPD: 88%; OR=0.49; 95%CI: 0.28 to 0.84) while alcohol consumption increasedit (drinker or ex-drinker: 95.8% vs non-drinker: 92.5%;OR=1.84; 95% CI: 1.01 to 3.33). Regarding tissue viability,decreased viability was observed in the presence ofCOPD (no COPD: 72.5% vs COPD: 64; OR=0.67; 95% CI:0.47 to 0.96) and diabetes mellitus (no diabetes: 72.9%vs diabetes: 67.2%; OR=0.76; 95% CI: 0.58 to 0.99). Asregards the viability of the implant, a total of 1039 corneas(68.9%) were suitable, observing decreased viability whensuffering from COPD (no COPD: 69.8% vs COPD: 60.7%;OR=0.67; 95% CI: 0.47 to 0.94) and increased whenhaving an active smoking habit (no habit: 65.3% vs habit:74.1%; OR=1.52; 95% CI: 1.21 to 1.91).Conclusions Through this study, it can be concluded thatin the absence of absolute exclusion criteria for donors, theassessment of how CVRF, alcoholism and COPD may affectthe donor provides details about the quality of the tissue tobe obtained. PB BMJ SN 2044-6055 LK https://hdl.handle.net/10612/21329 UL https://hdl.handle.net/10612/21329 NO Montero-Salinas, A., Martínez-Isasi, S., Fieira-Costa, E., Suanzes-Hernández, J., Fernández-García, D., Gómez-Salgado, J., & Rendal-Vazquez, E. (2023). Analysis of cardiovascular risk factors for the viability of cornea donors: A case-control study. BMJ Open, 13(12). https://doi.org/10.1136/BMJOPEN-2023-077122 DS BULERIA. Repositorio Institucional de la Universidad de León RD 25-jun-2024