RT info:eu-repo/semantics/article
T1 Regulatory feedback loop between TP73 and TRIM32
A1 González Cano, Laura
A1 Hillje, Anna-Lena 1983-
A1 Fuertes Álvarez, Sandra
A1 Marqués Martínez, Margarita
A1 Blanch, Álvaro
A1 Ian, R.W.
A1 Irwin, Meredith S.
A1 Schwamborn, Jens Christian
A1 Marín Vieira, María Carmen
A2 Biologia Celular
K1 Biología
K1 p73
K1 TRIM32
K1 Ubiquitination
K1 Transactivation
K1 E3 ligase
K1 Neural differentiation
K1 2407 Biología Celular
K1 3207.03 Carcinogénesis
AB [EN] The p73 transcription factor is one of the members of the p53 family of tumor suppressors with unique biological functions in processes like neurogenesis, embryonic development and differentiation. For this reason, p73 activity is tightly regulated by multiple mechanisms, including transcription and post-translational modifications. Here, we identified a novel regulatory loop between TAp73 and the E3 ubiquitin ligase tripartite motif protein 32 (TRIM32). TRIM32, a new direct p73 transcriptional target in the context of neural progenitor cells, is differentially regulated by p73. Although TAp73 binds to the TRIM32 promoter and activates its expression, TAp73-induced TRIM32 expression is efficiently repressed by DNp73. TRIM32 in turn physically interacts with TAp73 and promotes its ubiquitination and degradation, impairing p73-dependent transcriptional activity. This mutual regulation between p73 and TRIM32 constitutes a novel feedback loop, which might have important implications in central nervous system development as well as relevance in oncogenesis, and thus emerges as a possible therapeutic target
PB Springer Nature
LK https://hdl.handle.net/10612/21471
UL https://hdl.handle.net/10612/21471
NO Gonzalez-Cano, L., Hillje, A.-L., Fuertes-Alvarez, S., Marques, M. M., Blanch, A., Ian, R. W., Irwin, M. S., Schwamborn, J. C. and Marín, M. C. (2013). Regulatory feedback loop between TP73 and TRIM32. Cell Death & Disease, 4, Article e704. https://doi.org/10.1038/cddis.2013.224
DS BULERIA. Repositorio Institucional de la Universidad de León
RD Jul 12, 2024