RT info:eu-repo/semantics/article
T1 p73 is required for ependymal cell maturation and neurogenic SVZ cytoarchitecture
A1 González Cano, Laura
A1 Fuertes Álvarez, Sandra
A1 Robledinos Antón, Natalia
A1 Bizy, Alexandra
A1 Villena Cortés, Alberto José
A1 Fariñas, Isabel
A1 Marqués Martínez, Margarita
A1 Marín Vieira, María Carmen
A2 Biologia Celular
K1 Biología
K1 p73
K1 Ciliogenesis
K1 Ependymal cells
K1 Neurogenic pinwheel
K1 Planar cell polarity
K1 2407 Biología Celular
K1 3207 Patología
K1 2407.02 Citogenética
AB [EN] The adult subventricular zone (SVZ) is a highly organized microenvironment established during the first postnatal days when radial glia cells begin to transform into type B-cells and ependymal cells, all of which will form regenerative units, pinwheels, along the lateral wall of the lateral ventricle. Here, we identify p73, a p53 homologue, as a critical factor controlling both cell-type specification and structural organization of the developing mouse SVZ. We describe that p73 deficiency halts the transition of the radial glia into ependymal cells, leading to the emergence of immature cells with abnormal identities in the ventricle and resulting in loss of the ventricular integrity. p73-deficient ependymal cells have noticeably impaired ciliogenesis and they fail to organize into pinwheels, disrupting SVZ niche structure and function. Therefore, p73 is essential for appropriate ependymal cell maturation and the establishment of the neurogenic niche architecture. Accordingly, lack of p73 results in impaired neurogenesis. Moreover, p73 is required for translational planar cell polarity establishment, since p73 deficiency results in profound defects in cilia organization in individual cells and in intercellular patch orientation. Thus, our data reveal a completely new function of p73, independent of p53, in the neurogenic architecture of the SVZ of rodent brain and in the establishment of ependymal planar cell polarity with important implications in neurogenesis
PB Wiley
SN 1932-8451
LK https://hdl.handle.net/10612/21493
UL https://hdl.handle.net/10612/21493
NO González-Cano, L., Fuertes-Álvarez, S., Robledinos-Antón, N., Bizy, A., Villena-Cortés, A., Fariñas, I., Marqués, M.M. and Marín, M. C. (2016). p73 is required for ependymal cell maturation and neurogenic SVZ cytoarchitecture. Developmental Neurobiology, 76(7), 730-747. https://doi.org/10.1002/DNEU.22356
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 29-jun-2024