RT info:eu-repo/semantics/article
T1 Microsomal enzyme induction by permethrin in rats
A1 Anadón, A.
A1 Diez Liébana, María José
A1 Sierra Vega, Matilde
A1 Sánchez, J. A.
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Permethrin
K1 Ratas
K1 Enzyme
AB The synthetic pyrethroid, permethrin, was evaluated for its ability to alter hepatic microsomal drug-metabolizing function. The influence of permethrin (25:75 cis-trans) on plasma antipyrine kinetics and y-glutamyltranspeptidase (y-GTP) activity were studied in rats. After 3 days of administration of 90 mg permethrin/kg/day, there was no significant chage in the antipyrine half-life and the area under the curve, while the apparent volume of distribution and clearance were significantly increased. Tratment whith 190 mg permethrin/kg/day for 3 days decreased antipyrine half-life and the area under the curve, and incresed the apparent volume of distribution and the clearance sinificantly. The y-GTP activity was significantly incrased cithin 21 days and 14 days after the start of permethrin administration, at doses of 90 and 190 mg permethrin/kg/day, respectively. The antipyrine kinetics results indicate that permethrin is capable or producing a dose-dependent marked enzyme-inducing effect.
PB Springer
YR 2015
FD 2015-07-14
LK http://hdl.handle.net/10612/4394
UL http://hdl.handle.net/10612/4394
NO Veterinary and Human toxicology, 1988, n. 45
NO P. 309-312
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 25-abr-2024