RT info:eu-repo/semantics/article T1 Effects of slowed gastrointestinal motility on levodopa pharmacokinetics A1 Fernández, Nélida A1 García, Juan J. A1 Diez Liébana, María José A1 Sahagún , Ana M. A1 González, Aranzazu A1 Diez, Raquel A1 Sierra Vega, Matilde A2 Farmacologia K1 Ecología. Medio ambiente K1 Farmacología K1 Zoología K1 Biperiden K1 Levodopa K1 Pharmacokinetics K1 Rabbits K1 Slowed gastrointestinal motility K1 Farmacogenética K1 Ratones AB Autonomic disorders are often seen in Parkinson's disease, with disturbances of the gastrointestinal tractoccurring most frequently. These disorders, mainly a delay in gastric emptying and slowed gastrointestinalmotility, can modify the pharmacokinetics and effectiveness of drugs used to treat Parkinson's disease andadministered orally. In this study, we evaluated in a rabbit model the pharmacokinetics of levodopa(administered with carbidopa) in the context of gastrointestinal motility slowed by the administration of ananticholinergic drug. Levodopa+carbidopa (20:5 mg/kg) and the anticholinergic biperiden (100 μg/kg)were orally administered to rabbits over one of two time periods (7 or 14 days) to verify the stabilization oflevodopa concentrations. The values of the area under the curve (AUC) and Cmax were higher on the final dayof treatment with an increase in AUC of 25% on day 7 and 33.4% on day 14; for Cmax, the increase was 15% onday 7 and 12.8% on day 14. The values of AUC and Cmax were lower than those obtained when levodopawas administered to rabbits with normal gastrointestinal motility. The values obtained for Cmin (baselinesample obtained before administration) also increased with treatment duration (24% and 47.4% on days 7and 14, respectively). These values were higher than those obtained in the absence of anticholinergicadministration. We conclude that, under our experimental conditions of slowed gastrointestinal motility,levodopa absorption diminishes, and final concentrations and Cmin are higher than under conditions ofnormal motility. PB Elsevier YR 2015 FD 2015-07-29 LK http://hdl.handle.net/10612/4450 UL http://hdl.handle.net/10612/4450 NO Autonomic Neuroscience: Basic and Clinical, 2010, n. 156 NO P. 67-72 DS BULERIA. Repositorio Institucional de la Universidad de León RD 29-mar-2024