RT info:eu-repo/semantics/article
T1 The hydrosoluble fiber Plantago ovata husk improves levodopa (with carbidopa) bioavailability after repeated administration
A1 Diez Liébana, María José
A1 García, Juan J.
A1 Prieto, Carlos
A1 Fernández, Nélida
A1 Sahagún , Ana M.
A1 Sierra Vega, Matilde
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Levodopa bioavailability
K1 Carbidopa
K1 Plantago ovata husk
K1 Pharmacokinetics
K1 Rabbits
K1 Ratones
AB The influence of treatment duration (7 or 14 days) with Plantago ovata husk/levodopa/carbidopa in the bioavailability and otherpharmacokinetic parameters of levodopa were evaluated in rabbits. Fiber was administered at two different doses, 100 and 400 mg/kg, andthe dosage of levodopa/carbidopa was 20:5 mg/kg. These doses were administered once a day. When 100 mg/kg of fiber was administered,the mean AUC value obtained for levodopa increased 20.2% from day 1 to day 7, and 27.2% from day 1 to day 14; Cmax was 8.6% higher onday 7 and 11.7% higher on day 14. When administering 400 mg/kg of fiber, the increase in AUC values was 17.6% on day 7 and 24.9% onday 14, and that of Cmax 11.1% on day 7 and 11.3% on day 14. The concentration determined immediately before drug administration (Cmin)increased progressively with the duration of treatment, and the highest increase (53.2%) was observed on day 14 with 100 mg/kg of fiber.There was also a delay in levodopa elimination (higher MRT and lower Cl) in a fiber-dose dependent manner. In summary, we found thatthere was an improvement in the extent of levodopa absorbed with higher final concentrations and that levodopa elimination was slower withthe administration of P. ovata husk.
PB Elsevier
YR 2015
FD 2015-07-31
LK http://hdl.handle.net/10612/4472
UL http://hdl.handle.net/10612/4472
NO Journal of the neurological , 2008, n. 271
NO P. 15-20
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 18-abr-2024