RT info:eu-repo/semantics/article
T1 Bioavailability  of  levamisole after  intramuscular and oral  administration  in  sheep
A1 Fernández, Nélida
A1 García, Juan J.
A1 Sierra Vega, Matilde
A1 Diez Liébana, María José
A1 Terán Somaza, María Teresa
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Levamisole
K1 Bioavailability
K1 Sheep
AB Aims. To determine the bioavailability  of levamisole in sheep.Methods. Levamisole was administered to three groups of six Merino sheep orally and intramuscularly at three dose levels of 5, 7.5 and 1O mg/kg. There was a washout period of 1 week between treatments. Blood samples were collected by jugular venepuncture and plasma was separated immediately by centrifugation and stored at - 20 ºC until analysed.The levamisole concentration in plasma was determined by high performance liquid chromatography with a u.v. detection method. Individual plasma levamisole concentration-time data were analysed using the compartmental method.Results. The values obtained for ka , Cmax , tmax and F show a moderate  rate and extent of absorption after oral administration of levamisole while, after intramuscular administration, these values demonstrate a high rate and extent of absorption of levamisole. The intramuscular bioavailability was higher than the oral bioavailability (rate of absorption three-fold faster, extent of absorption 2.5 -33% higher and Cmax.. two-fold higher). The Friedman test involving dose and route of administration showed that the route of administration affects ka, Cmax' tmax and F; significant differences were found in these parameters.Clinical relevance. On the basis of these data, the recommended  routes  for  the  administration  of  levamisole  in sheep are oral for gastro-intestinal  nematodiasis  and intramuscular for extragastric nematodiasis.
PB Taylor and Francis
YR 2015
FD 2015-08-19
LK http://hdl.handle.net/10612/4529
UL http://hdl.handle.net/10612/4529
NO New Zealand Veterinary Journal, 1998,n.46
NO P. 173-176
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 19-abr-2024