RT info:eu-repo/semantics/article
T1 Bioavailability of levamisole administered by subcutaneous and oral routes in rabbits
A1 García, Juan J.
A1 Diez Liébana, María José
A1 Sierra Vega, Matilde
A1 Terán Somaza, María Teresa
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Bioavailability
K1 Levamisole
K1 Oral routes
K1 Subcutaneous
AB The bioavailability of levamisole in rabbits was determined after subcutaneous and oral administration  at three dose levels of  12.5, 16.0 and 20.0 mg/kg.After non-compartmental analysis the mean values obtained were: Cmax = 3.54, 4.51 and 5.39 µg/ml; tmax = 12.0, 22.0 and 20.0 min;  F = 134.8, 105.4 and124.1% after subcutaneous administration for each dose, respectively, and Cmax= 0.71, 1.32 and 1.77 µg/ml; tmax = 46.0, 96.0 and 84.0 min; F = 53.0, 62.0and 80.7% after oral administration. The extent and rate of absorption from the two routes differed sign.ificantly, except for tmax at the 12.5 mg/kg dose. After compartmental analysis the pharmacokinetics of levamisole was characteristic of a two-compartment open model in 13 rabbits and of a one-compartment open model in two rabbits after subcutaneous administration, while it was two compartmental in nine and one compartmental in six rabbits after oral admini­ stration. The kª values were 0.321, 0.145 and 0.145 min-1 after subcutaneousadininistration and 0.054, 0.023 and 0.027 min- 1 after oral administration. There were no significant differences between the values of Cmax• tmax and AUC calculated by compartmental and non-compartmental analysis.
PB Blackwell Scientific Publications
YR 2015
FD 2015-08-19
LK http://hdl.handle.net/10612/4530
UL http://hdl.handle.net/10612/4530
NO Journal of Veterinary Pharmacology and Therapeutics, 1994, n. 17
NO P. 135-140
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 24-abr-2024