RT info:eu-repo/semantics/article
T1 Bioavailability of a commercial formulation of ivermectin after subcutaneous administration to sheep
A1 González, Aranzazu
A1 Sahagún , Ana M.
A1 Diez Liébana, María José
A1 Fernández, Nélida
A1 Sierra Vega, Matilde
A1 García, Juan J.
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Bioavailability
K1 Commercial formulation
K1 Ivermectin
K1 Sheep
AB Objective-To evaluate bioavailability and other pharmacokinetic variables of a commercial formulation of ivermectin after IV administration to sheep.Animals-6 healthy adult sheep.Procedures-A single dose of a commercial formulation  of  ivermectin  (200 µg/kg) wasadministered IV to each sheep. After a washout period of 3 weeks,  each sheep was administered ivermectin by Se injection. Plasma samples were obtained for up to 36 andup to 42 days after IV and se administration, respectively. lvermectin concentrations werequantified by use of high-performance liquid chromatography with fluorescence detection.Results-Results obtained indicated that after IV administration, ivermectin is cleared slowly from plasma, tends to distribute and accumulate in the peripheral compartment, andis slowly eliminated from the body. After se administration, noncompartmental analysisrevealed that bioavailability of ivermectin is nearly complete (98.20%), has a slow mean absorption time of 0.96 days, and reaches a maximum plasma concentration of 19.55 ng/ ml at 3.13 days.Conclusions and Clinical Relevance-The commercial formulation of ivermectin used in this study can be administered se to sheep on the basis of a nearly complete bioavailability. Inaddition, the maximum plasma concentration and interval from se injection until maximumplasma concentration is obtained are higher than those reported by other authors who used other routes of administration.
PB American Veterinary Medical Assn.
YR 2015
FD 2015-08-19
LK http://hdl.handle.net/10612/4532
UL http://hdl.handle.net/10612/4532
NO American journal research, 2007, n. 68
NO P. 101-106
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 25-abr-2024