RT info:eu-repo/semantics/article
T1 A  Review  of  the  Pharmacological  lnteractions  of  Ivermectin  in  Several Animal Species
A1 González, Aranzazu
A1 Fernández, Nélida
A1 Sahagún , Ana M.
A1 Diez Liébana, María José
A1 Sierra Vega, Matilde
A1 García, Juan J.
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Ivermectin
K1 Pharmacokinetic interactions
K1 Pharmacodynamic interactions
K1 Veterinary
AB Abstract: The antiparasitic activity of ivermectin depends 011 the presence of an active drug concentration at the site of parasites location for an adapted length of time. lvermectin interactions with another concurrently administered drug can occur. Concomitant administration of sorne drugs can increase the bioavailability of simultaneously administered ivermectin. This can, in sorne cases, become a useful pharmacological strategy to improve its antiparasitic efficacy and to delay the development of resistance in livestock or, in other cases, lead to adverse drug reactions and toxicities. On the other hand, other interactions can result in lower levels of this drug, determining that moderate resistant residual populations of the parasites may persist to contarninate pastures. The characterisation of ivermectin interac­ tions can be used to predict and optimisc the valúe of the parasiticide effects. This article reviews the pharmacological interactions of ivermectin in several domestic animal species.
PB Bentham Science Publishers
LK http://hdl.handle.net/10612/4533
UL http://hdl.handle.net/10612/4533
NO Current Drug Metabolism, 2009, n.10
NO P. 359-368
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 25-abr-2024