RT info:eu-repo/semantics/article
T1 Pharmacokinetics of levamisole in sheep after intravenous administration
A1 Fernández, Nélida
A1 García, Juan J.
A1 Sierra Vega, Matilde
A1 Diez Liébana, María José
A1 Terán Somaza, María Teresa
A2 Farmacologia
K1 Farmacología
K1 Zoología
K1 Pharmacokinetics
K1 Levamisole
K1 Sheep
K1 Intravenous administration
AB The pharmacokinetics of levamisole at doses of 5, 7.5 and 10 mg/kg were determined after its intravenous administration to eighteen healthy Merino sheep. Using compartmental analysis, the disposition of the drug best fitted a two-compartmental open model. The mean values for the compartmental volume of distribution at steady state (Vss) were 2.034 ± 0.231, 2.347 ± 0.720 and2.001 ± 0.367 l/kg for each dose, respectively, and values obtained using the statistical moment theory were 2.141 ± 0.269, 2.390± 0.536 and 2.140 ± 0.345 l/kg for each dose, respectively. There were no dose-related differences (one-way ANOVA) in the constants describing distribution and elimination phases (α and β) or Vss but significant differences were detected in the total body clearance (CI) and the area under the plasma concentration-time curve (AUC). After non-compartmental analysis, no significant differences were found when the parameters λ. (the linear terminal slope) and Vss were compared, but significant differences were detected in CI and AUC. There were no significant differences between the values obtained using the compartmental and non­ compartmental analysis when λ.- β, CI, V,, and AUC were compared.
PB New Zealand veterinary association
YR 2015
FD 2015-09-04
LK http://hdl.handle.net/10612/4563
UL http://hdl.handle.net/10612/4563
NO New Zealand Veterinary Journal, 1997, n. 45
NO P. 63-66
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 19-abr-2024