RT info:eu-repo/semantics/article
T1 Evolution of the bioavailability and other pharmacokinetic parameters of levodopa (with carbidopa) in rabbits
A1 Fernández, Nélida
A1 Prieto, Carlos
A1 Sierra Vega, Matilde
A1 Diez Liébana, María José
A1 Sahagún , Ana M.
A1 González, Aranzazu
A1 García, Juan J.
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Carbidopa
K1 LAAD inhibitors
K1 Levodopa
K1 Pharmacokinetics
K1 Rabbits
AB Levodopa pharmacokinetics show i111portanl inter- and intraindividual dijferences when it is administered by the oral route. As a result of fluctu­ ating drug plasma concentrations, patients may develop motor fluctuations and dyskinesias. Therefore, it is in1portanl tope1form studies on levodopa pharmacokinetics in the same individual. The aim of this sh1dy was to contribute to a better knowledge of the evolution of thephannacokinetics of lev­ adopa adnúnislered ivith carbidopa. The study involved the oral administration of 20/5 mg/kg levodopa/carbidopa to rahbits for two different time periods (7 or 14 days), due to the fact that inhibition of aromatic L-amino-acid decarboxylase by carbidopa is not immediate. After 7 days of treat­ ment, the levodopa AUC increased by 12.6%.fivm day 1 (range: 114.2-150.7 µg.min/ml) to day 7 (range: 131.1-166.0 µg.min/ml) and C"'ª" increased by 9.6% (range: 1.90-2.86 µg/ml on day 1 and 2.12-3.13 µglml on day 7). After 14 days of treatment, the increase in AUC was 17.0% (range: 119.6-160.1 µg.min/ml on day 1 and 142.9-172.7 ¡ µg.min/ml on day 14) and Cmax increased by 6.5% {tange: 2.29-2.96 µg!ml on day 1 and 2.41·-3.07µg/ml on day 14). The values obtained for C,max (sample obtained im1nediately befare levodopa/carbidopa administration) in both grups increased progressively with the duration of the treatment. Cmax and  AUC values were very similar after 7 or 14 days of treatment. The time needed far Cm,in sta­ bilization was slightly highe1; because we found significant djfferences until day 11 of treatment.
PB Prous Science
YR 2015
FD 2015-09-04
LK http://hdl.handle.net/10612/4564
UL http://hdl.handle.net/10612/4564
NO Methods and Findings in Experimental and Clinical Pharmacology, 2008, n. 30
NO P. 451-457
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 27-abr-2024