RT info:eu-repo/semantics/article
T1 Pharmacokinetics of a novel formulation of ivermecti n after administration to goats
A1 González, Aranzazu
A1 Sahagún , Ana M.
A1 Diez Liébana, María José
A1 Fernández, Nélida
A1 Sierra Vega, Matilde
A1 García, Juan J.
A2 Farmacologia
K1 Farmacología
K1 Medicina. Salud
K1 Pharmacokinetics
K1 Ivermectin
K1 Goats
AB Objective-To evaluate the pharmacokinetics of a novel commercial formulation of ivermectin after administration to goats .Animals-6 healthy adult goats.Procedure-lvermectin (200 µg/kg) was initially administered IV to each goat, and plasma samples were obtained for 36 days. After a washout period of 3 weeks, each goat received a novel commercial for­ mulation of ivermectin (200 µg/kg) by se injection. Plasma samples were then obtained for 42 days. Drug concentrations were quantified by use of high­ performance liquid chromatography with fluores­ cence detection.Results-Pharmacokinetics of ivermectin after IV administration were best described by a 2-compart­ ment open model; values for main compartmental variables included volume of distribution at a steady state (9.94 L/kg), clearance (1.54 L/kg/d), and area under  the  plasma  concentration-time  curve  (AUC;143 [ng•dl/ml) . Values for the noncompartmental variables included mean residence time (7.37 days). AUe (153 [ng•dl/ml). and clearance (1.43 L/kg/d). After se administration, noncompartmental pharma­ cokinetic analysis was conducted . Values of the vari­ ables calculated by use of this method included max­ imum plasma concentration (Cmax; 21.8 ng/ml), time to reach Cmax (3 days). and bioavailability (F; 91.8%) .Conclusions and Clinical Relevance-The commer­ cial formulation used in this study is a good option to consider when administering ivermectin to goats because of the high absorption, which is character­ ized by high values of F. In addition, the values of Cmax and time to reach Cmax are higher than those reported by other investigators who used other routes of administration.
PB American Veterinary Medical Assn.
YR 2015
FD 2015-09-04
LK http://hdl.handle.net/10612/4565
UL http://hdl.handle.net/10612/4565
NO American Journal of Veterinary Research, 2006, vol. 67, n. 2
NO P. 323-328
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 27-abr-2024