RT info:eu-repo/semantics/article
T1 Pharmacokinetics of doxycycline in sheep after intravenous and oral administration
A1 Castro, Luis J.
A1 Sahagún , Ana M.
A1 Diez Liébana, María José
A1 Fernández, Nélida
A1 Sierra Vega, Matilde
A1 García, Juan J.
A2 Farmacologia
K1 Farmacología
K1 Veterinaria
K1 Zoología
K1 Pharmacokinetics
K1 Dosycycline
K1 Sheep
K1 Intravenous
K1 Oral
AB The pharmacokinetics of doxycycline were investigated in sheep after oral (PO) and intravenous (IV) administration. The IV data werebest described using a 2- (n = 5) or 3- (n = 6) compartmental open model. Mean pharmacokinetic parameters obtained using a 2-compartmentalmodel included a volume of distribution at steady-state (Vss) of 1.759 ± 0.3149 L/kg, a total clearance (Cl) of 3.045 ± 0.5264 mL/kg/min and an elimination half-life (t1/2b) of 7.027 ± 1.128 h. Comparative values obtained from the 3-compartmental mean values were:Vss of 1.801 ± 0.3429 L/kg, a Cl of 2.634 ± 0.6376 mL/kg/min and a t1/2b of 12.11 ± 2.060 h. Mean residence time (MRT0_1) was11.18 ± 3.152 h. After PO administration, the data were best described by a 2-compartment open model. The pharmacokinetic parametermean values were: maximum plasma concentration (Cmax), 2.130 ± 0.950 lg/mL; time to reach Cmax (tmax), 3.595 ± 3.348 h, and absorptionhalf-life (t1=2k01 ), 36.28 ± 14.57 h. Non-compartmental parameter values were: Cmax, 2.182 ± 0.9117 lg/mL; tmax, 3.432 ± 3.307 h;F, 35.77 ± 10.20%, and mean absorption time (MAT0–∞), 25.55 ± 15.27 h. These results suggest that PO administration of doxycyclinecould be useful as an antimicrobial drug in sheep.
PB Elsevier
YR 2015
FD 2015-09-04
LK http://hdl.handle.net/10612/4571
UL http://hdl.handle.net/10612/4571
NO The Veterinary Journal, 2009, n. 180
NO P. 389-395
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 26-abr-2024