RT info:eu-repo/semantics/article
T1 Study of the pharmacokinetic interaction between ethinylestradiol and amoxicillin in rabbits
A1 Fernández, Nélida
A2 Farmacologia
K1 Farmacología
K1 Veterinaria
K1 Ethinylestradiol
K1 Amoxicillin
K1 Pharmacokinetic interactions
K1 Rabbits
K1 Oestrogens
AB Several antibiotics have been implicated in oral contraception failure when they are administered at the same time as the oral contraceptive (OC) pill. In the present paper, a study about amoxicillin-ethinylestradiol (EE22 pharmacokinetic potential interaction was studied. Two rabbit groups were utilized, the first group received amoxicillin (10 mg/kg) and EE 22 (30, 50 and 100 µg/kg, respectively), both by intravenous (i.v.) route. The second group received amoxicillin (oral route, 10 mg/kg/day) and EE 22 (i.v. route, 100 µ/kg)  on day  1,4 and  8 of  antibiotic  treatment, respectively. After compartmental (two-compartment open model) and non-compartmental analysis of plasma concentrations, the statistical study (ANOVA p< 0.05) revealed that the presence of amoxicillin did not modify the EE 22  distribution and elimination pharmacokinetic parameters (by comparison with those obtained in a previous stud y where E22  was administered alone). There also were no significant differences with the time of amoxicillin oral treatment.
PB Elsevier
YR 2015
FD 2015-09-04
LK http://hdl.handle.net/10612/4572
UL http://hdl.handle.net/10612/4572
NO Contraception, 1997, n. 55
NO P. 47-52
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 25-abr-2024