RT info:eu-repo/semantics/article
T1 Pharmacokinetics of levamisole in rabbits after intravenous administration
A1 García, Juan J.
A1 Diez Liébana, María José
A1 Sierra Vega, Matilde
A1 Terán Somaza, María Teresa
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Veterinaria
K1 Pharmacokinetics
K1 Levamisole
K1 Intravenous administration
K1 Rabbits
AB A compartmental and non-compartmental pharmacokinetic  study  was carried out on rabbits after intravenous (i.v.) administration  of  levamisole  al  the  three dose rales: 12.5. 16.0  and  20.0  mg/kg  body  weight.  Using  compartmental analysis, the disposition of levamisole best fitted a  t wo-compartmental  open model with  mean values of α= 0.1278, 0. 1019 and 0.1282 mi n - 1 ;  β =0.0139O.O 126 and 0.0124 min- 1 ; A = 6 .24. 5.27 and 10.58 µg/ml and  β = 2.14. :3083and 5.08 µg/ml for each dose, respectively. The statistical moment theory was mainly used for non-compartmental analysis. Values for mean residence time (MRT) of 69.2, 71 .7 and 73. 1 min were obtained for each dose. The mean values for volume of dist ribution at steady state ( Vd(ss)). determined by compartmental analysis, were 3879. 3 279 and 2735 ml/kg for each dose. and values obtained using the statistical moment theory were :3760. 3015 and 2943 ml/kg; there were no statistically significant differences using Student's paired 1-lest. Identical conclusions were obtained using both methods  when  the  parameters   β. AUC and  Cl  were  compared.
PB Wiley-Blackwell
YR 2015
FD 2015-09-04
LK http://hdl.handle.net/10612/4576
UL http://hdl.handle.net/10612/4576
NO Journal of Veterinary Pharmacology and Therapeutics, 1992, n. 15
NO P. 85-90
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 19-abr-2024