RT info:eu-repo/semantics/article
T1 Hypoglycemic and hypolipidemic potential of a high fiber diet in healthy versus diabetic rabbits
A1 Diez Liébana, María José
A1 García, Juan J.
A1 Diez, Raquel
A1 Sierra Vega, Matilde
A1 Sahagún , Ana M.
A1 Calle Pardo, Ángela Pilar
A1 Fernández, Nélida
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Veterinaria
K1 Zoología
K1 Hypoglycemic
K1 Hypolipidemic
K1 High fiber diet
K1 Diabetic
K1 Rabbits
AB The aim of this study was to investigate potential hypoglycaemic and hypolipidemic effects of Plantago ovata husk included in thediet, in healthy and diabetic rabbits. We also examined the effects of this fiber in other biochemical parameters. Two groups of18 rabbits were used.The first group was fed with standard chow and the second with chow supplemented with Plantago ovatahusk (3.5mg/kg/day). On day 14 diabetes mellitus was induced by the intravenous administration of alloxan (80mg/kg). After anoral glucose load (3 g), glucose, insulin, and other biochemical parameters were determined on day 14 (healthy rabbits) and on day28 (diabetic rabbits). In healthy rabbits, fiber did not modify glucose or insulin levels but decreased significantly total cholesterol,LDL-cholesterol, atherogenic index, and glycosylated hemoglobin. In diabetic rabbits, fiber was more beneficial in mild diabeticsthan in severe diabetics with significant decreases in glucose levels and increases in insulin concentrations. In these animals fibercaused an important reduction in cholesterol, indicating a beneficial effect of Plantago ovata husk in diabetic rabbits. Althoughfurther studies in patients are necessary, we think that Plantago ovata husk offers interesting perspectives to be administered topatients with diabetes mellitus.
PB Hindawi
YR 2015
FD 2015-10-21
LK http://hdl.handle.net/10612/4704
UL http://hdl.handle.net/10612/4704
NO Biomed research international, 2013
NO P. 960568 - 960575
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 08-may-2024