RT info:eu-repo/semantics/article
T1 Systemic and mammary gland disposition of enrofloxacin in healthy sheep following intramammary administration
A1 López, Cristina
A1 García, Juan J.
A1 Sierra Vega, Matilde
A1 Diez Liébana, María José
A1 Pérez
A1 Sahagún , Ana M.
A1 Fernández, Nélida
A2 Farmacologia
K1 Farmacología
K1 Sanidad animal
K1 Veterinaria
K1 Zoología
K1 Enrofloxacin
K1 Sheep
K1 Intramammary
K1 Systemic
K1 Glandular tissue
K1 Disposition
AB Background: Mastitis is one of the most important diseases affecting dairy sheep. Antimicrobial drugs are oftenadministered directly through teat to treat or prevent this disease, but data on drug distribution within glandulartissue are scarce and it cannot be estimated from concentrations in milk. Thus, the aim of this study was toinvestigate systemic and mammary gland distribution of enrofloxacin after intramammary administration. Thedrug was administered to 6 healthy lactating Assaf sheep with an injector containing an enrofloxacin preparation(1 g drug/5 g ointment). Blood samples were collected at 0, 30, 60, 90, 120, 150 and 180 min. Animals were thensedated and sacrificed, and glandular tissue samples were obtained from treated udders at 2, 4, 6 and 8 cm height.Enrofloxacin concentrations were measured in plasma and tissue samples by UV high-performed liquid chromatography.Results: Mean enrofloxacin plasma concentrations were below 0.5 μg/mL. Mean tissue concentrations decreased inmammary gland with vertical distance from the teat, ranging from 356.6 μg/g at 2 cm to 95.60 μg/g at the base of theudder. Glandular tissue concentrations best fitted to a decreasing monoexponential model, and showed a goodcorrelation with an ex vivo model previously developed.Conclusions: Enrofloxacin concentrations were effective in the entire glandular tissue against the main pathogenscausing mastitis in sheep. These results suggest that this drug may be suitable to treat mastitis in sheep byintramammary administration.
PB Biomed central
YR 2015
FD 2015-10-21
LK http://hdl.handle.net/10612/4706
UL http://hdl.handle.net/10612/4706
NO BMC veterinary research, 2015, n. 11
NO P. 88-94
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 19-abr-2024