RT info:eu-repo/semantics/article
T1 Study of the protective effect on intestinal mucosa of the hydrosoluble fiber Plantago ovata husk
A1 Sahagún , Ana M.
A1 Vaquera Orte, José
A1 García, Juan J.
A1 Calle Pardo, Ángela Pilar
A1 Diez Liébana, María José
A1 Fernández, Nélida
A1 Loro, Juan F.
A1 Portilla Portilla, Hugo Orlando
A2 Farmacologia
K1 Farmacología
K1 Plantago ovata husk
K1 Intestinal lessions
K1 Fiber
K1 Anti-ulcerogenic effect
K1 Rabbits
AB Background: Several studies have indicated that dietary fiber may have a protective effect on gastrointestinal mucosa.The aim of this study was to evaluate the protective action of the soluble fiber Plantago ovata husk against intestinaldamage.Methods: To evaluate the anti-ulcerogenic effect on duodenal mucosa of the soluble fiber Plantago ovata husk,low-dose acetylsalicylic acid (10 mg/kg) was given orally to animals once daily for 14 or 28 days with and withoutPlantago ovata husk (100 mg/kg). 24 h after final dosing duodenal samples were removed for anatomopathologicalevaluation. Villi were examined by both light and scanning electron microscopy.Results: Acetylsalicylic acid induced severe lesions in duodenal mucosa of rabbits, including erosions, epitheliumdisorganization, and cell vacuolization, increasing as well the amount of mononuclear and caliciform cells. Damage wasmuch more severe in animals treated for 28 days. In groups receiving Plantago ovata husk, a significant attenuation ofacetylsalicylic acid-induced lesions was already observed in group treated for 14 days, becoming more evident in thosetreated for 28 days, all of them with duodenal cytoarchitecture normal and similar to control animals.Conclusions: These findings suggest that Plantago ovata husk may protect intestinal mucosa probably by limitingacetylsalicylic acid penetration into epithelial cells, although further studies are needed to confirm the same effect inother experimental models of induced mucosal damage and to elucidate the mechanisms of fiber protection.
PB Biomed central
YR 2015
FD 2015-10-26
LK http://hdl.handle.net/10612/4714
UL http://hdl.handle.net/10612/4714
NO BMC complementary & alternative medicine , 2015,vol. 15, n. 298
NO P. 23-45
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 23-abr-2024