RT info:eu-repo/semantics/preprint
T1 Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy
A1 Pisonero-Vaquero, Sandra
A1 González Gallego, Javier
A1 Sánchez-Campos, Sonia
A1 García Mediavilla, María Victoria
A2 Otros
K1 Medicina. Salud
K1 Non-alcoholic fatty liver disease (NAFLD)
K1 Antioxidant
K1 Flavonoids
K1 Insulin resistance
AB Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome,is one of the most common chronic liver diseases, which may progress to fibrosis, cirrhosis andhepatocellular carcinoma. NAFLD is characterized by the accumulation of lipids in the liver arising frommultiple factors: increased fatty acid uptake, increased de novo lipogenesis, reduced fatty acid oxidationand very low density lipoproteins (VLDL) secretion. Most therapeutic approaches for this disease areoften directed at reducing body mass index and improving insulin resistance through lifestylemodifications, bariatric surgery and pharmacological treatments. Nevertheless, there is increasingevidence that the use of natural compounds, as polyphenols, exert multiple benefits on the disordersassociated with NAFLD. These molecules seem to be able to regulate the expression of genes mainlyinvolved in de novo lipogenesis and fatty acid oxidation, which contributes to their lipid-lowering effectin the liver. Their antioxidant, anti-inflammatory, antifibrogenic and antilipogenic properties seem toconfer on them a great potential as strategy for preventing NAFLD progression. In this review, wesummarized the effects of these compounds, especially flavonoids, and their mechanisms of action, thathave been reported in several studies carried out in in vitro and in vivo models of NAFLD
PB Bentham Science Publishers
YR 2016
FD 2016-12-19
LK http://hdl.handle.net/10612/5685
UL http://hdl.handle.net/10612/5685
NO Current Medicinal Chemistry, 2015, 22
NO P. 2991-3012
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 25-abr-2024