RT info:eu-repo/semantics/article
T1 Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
A1 Castaño Labajo, Pablo
A1 Fuertes Franco, Miguel
A1 Ferre, I
A1 Fernández Fernández, Miguel
A1 Ferreras, MC
A1 Moreno-Gonzalo, J
A1 González-Lanza, C
A1 Katzer, F
A1 Regidor-Cerrillo, J
A1 Ortega-Mora, LM
A1 Pérez, V
A1 Benavides Silván, Julio
A2 Sanidad Animal
K1 Veterinaria
AB After oral administration of ewes during mid gestation with 2000 freshly prepared sporulated oocysts of T. gondiiisolate M4, abortions occurred between days 7 and 11 in 91.6% of pregnant and infected ewes. Afterwards, afurther infection was carried out at late gestation in another group of sheep with 500 sporulated oocysts. Abortionshappened again between days 9 and 11 post infection (pi) in 58.3% of the infected ewes. Classically, abortions innatural and experimental ovine toxoplasmosis usually occur one month after infection. Few experimental studieshave reported the so-called acute phase abortions as early as 7 to 14 days after oral inoculation of oocysts, andpyrexia was proposed to be responsible for abortion, although the underline mechanism was not elucidated. In thepresent study, all placentas analysed from ewes suffering acute phase abortions showed infarcts and thrombosis inthe caruncullar villi of the placentomes and ischemic lesions (periventricular leukomalacia) in the brain of somefoetuses. The parasite was identified by PCR in samples from some placentomes of only one sheep, and no antigenwas detected by immunohistochemical labelling. These findings suggest that the vascular lesions found in theplacenta, and the consequent hypoxic damage to the foetus, could be associated to the occurrence of acute phaseabortions. Although the pathogenesis of these lesions remains to be determined, the infectious dose or virulenceof the isolate may play a role in their development
YR 2016
FD 2016-12-23
LK http://hdl.handle.net/10612/5693
UL http://hdl.handle.net/10612/5693
NO Veterinary Research, 2014, 29, 45
NO 43 p.
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 26-abr-2024